Thesaurus for histopathological findings in publically available reports of repeated-dose oral toxicity studies in rats for 156 chemicals

Because histopathological findings are often conclusive indicators of the toxicities of chemicals, standardization of nomenclature and construction of a thesaurus for histopathological findings are important for the comparative evaluation of histopathological data from repeated-dose toxicity studies...

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Bibliographic Details
Published in:Journal of toxicological sciences 2010/06/01, Vol.35(3), pp.295-298
Main Authors: Nishikawa, Satoshi, Yamashita, Tatsuhiro, Imai, Toshio, Yoshida, Midori, Sakuratani, Yuki, Yamada, Jun, Maekawa, Akihiko, Hayashi, Makoto
Format: Article
Language:English
Subjects:
Administration, Oral
Animals
Chemical compounds
Dose-Response Relationship, Drug
Drug-Related Side Effects and Adverse Reactions
Endocrine System - drug effects
Endocrine System - pathology
Histopathological findings
Kidney - drug effects
Kidney - pathology
Liver - drug effects
Liver - pathology
Pathology thesaurus
Rat
Rats
Repeated-dose oral toxicity studies
Stomach - drug effects
Stomach - pathology
Time Factors
Toxicity Tests - methods
Vocabulary, Controlled
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Summary:Because histopathological findings are often conclusive indicators of the toxicities of chemicals, standardization of nomenclature and construction of a thesaurus for histopathological findings are important for the comparative evaluation of histopathological data from repeated-dose toxicity studies (RTS). However, terms for histopathological findings have not been standardized and different technical terms are used to indicate almost the same thing in RTS. The present study was conducted to construct an easy-to-use thesaurus for histopathological findings in order to facilitate hazard assessments of untested chemicals by the category approach using knowledge of the toxicity of analogue chemicals. We used reports of 28-day RTS, conducted on rats by gavage, which were posted on the websites of the National Institute of Health Sciences (NIHS) and the National Institute of Technology and Evaluation (NITE). The histopathological data were from 156 reports on RTS conducted by 13 institutions in Japan. As a result of this study, major parts of the thesaurus were devoted to the findings in the liver, kidney, stomach, adrenal, thyroid and testis; the first three organs are known to be the main targets of chemicals. We also decided that findings such as swelling and enlargement of hepatocytes should be categorized as synonyms for terms meaning hypertrophy. Our thesaurus will be helpful in assessing or screening new untested chemicals by the category approach using knowledge of the toxicities of analogues of the new chemical. The RTS database with this thesaurus will be made publically available in 2012.
ISSN:0388-1350
1880-3989
DOI:10.2131/jts.35.295