Comparison of platelet, leukocyte, and growth factor levels in point-of-care platelet-enriched plasma, prepared using a modified Curasan kit, with preparations received from a local blood bank

: The potential use of autologous thrombocytic growth factors to accelerate bone regeneration requires improved methods of isolating platelet‐rich plasma (PRP). In addition to discontinuous cell separation, a second method by which PRP is produced at the point‐of‐care has now become available. In th...

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Bibliographic Details
Published in:Clinical oral implants research 2003-06, Vol.14 (3), p.357-362
Main Authors: Weibrich, Gernot, Kleis, Wilfried K.G., Hafner, Gerd, Hitzler, W.E., Wagner, Wilfried
Format: Article
Language:English
Subjects:
Adult
Blood Banks
Blood Specimen Collection
Cell Separation
Dentistry
discontinuous cell separation
Female
Growth Substances - blood
Humans
insulin-like growth factor
Insulin-Like Growth Factor I - analysis
Leukocyte Count
Male
Middle Aged
platelet concentrate
Platelet Count
Platelet Transfusion
platelet-derived growth factor
Platelet-Derived Growth Factor - analysis
platelet-rich plasma
Point-of-Care Systems
Statistics, Nonparametric
transforming growth factor
Transforming Growth Factor beta - analysis
Transforming Growth Factor beta1
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Summary:: The potential use of autologous thrombocytic growth factors to accelerate bone regeneration requires improved methods of isolating platelet‐rich plasma (PRP). In addition to discontinuous cell separation, a second method by which PRP is produced at the point‐of‐care has now become available. In this study, growth factor levels in PRP from these two sources were compared. Whole blood was drawn from 115 healthy donors (73 males, 42 females) aged 21 – 62 years (mean 36, SD 10). The PRP was separated by the blood bank (BB) using the discontinuous cell separation method or at the ‘point‐of‐care’ by the so‐called ‘buffy coat’ method (analogous to the Curasan PRP Kit). Growth factor content differed significantly for TGF‐β1 (BB 268.65±70.77 ng/ml, Curasan 95.02±60.67 ng/ml (sign test P
ISSN:0905-7161
1600-0501
DOI:10.1034/j.1600-0501.2003.00810.x