Quantitative trait loci for periosteal circumference (PC): identification of single loci and epistatic effects in F2 MRL/SJL mice

To test the hypothesis that periosteal circumference (PC), which is associated with bone size through cross-sectional moment of inertia (CMI), has heritable components, we performed a linkage analysis using 633 MRL/SJL F(2) mice that have 14% difference in mean PC. PC was determined in femurs by use...

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Bibliographic Details
Published in:Bone (New York, N.Y.) N.Y.), 2003-05, Vol.32 (5), p.554-560
Main Authors: MASINDE, G. L, WERGEDAL, J, DAVIDSON, H, MOHAN, S, LI, R, LI, X, BAYLINK, D. J
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Body Weight - genetics
Epistasis, Genetic
Female
Femur - anatomy & histology
Femur - physiology
Genome
Investigative techniques, diagnostic techniques (general aspects)
Lod Score
Male
Medical sciences
Mice
Mice, Inbred Strains
Osteoarticular system. Muscles
Periosteum - anatomy & histology
Periosteum - physiology
Quantitative Trait Loci
Radiodiagnosis. Nmr imagery. Nmr spectrometry
Species Specificity
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Summary:To test the hypothesis that periosteal circumference (PC), which is associated with bone size through cross-sectional moment of inertia (CMI), has heritable components, we performed a linkage analysis using 633 MRL/SJL F(2) mice that have 14% difference in mean PC. PC was determined in femurs by use of peripheral quantitative computerized tomography (pQCT). The genome-wide scan identified nine QTL for PC adjusted by body weight on chromosomes 1 (2 QTL), 2 (2 QTL), 8, 11, 15, 17, and X, which accounted for 38.6% of phenotype variance. QTL on chromosomes 1 (D1Mit33), 8 (D8Mit125), 15 (D15Mit 62), 17 (D17Mit176), and X (DXMit208) were unique for PC adjusted by body weight and femur length, while the remaining PC QTL were shared with body weight but not femur length. Four epistatic interactions were identified which accounted for 37.6% of phenotype variance. There was also evidence of pleiotropic effects on chromosome 11 among four size phenotypes (PC, body length, body weight, bone mineral density, and muscle size), which may represent a common genetic mechanism that may regulate bone size and body size.
ISSN:8756-3282
1873-2763
DOI:10.1016/S8756-3282(03)00063-2