Early events in valvulogenesis: A signaling perspective

The proper formation and function of the vertebrate heart requires a multitude of specific cell and tissue interactions. These interactions drive the early specification and assembly of components of the cardiovascular system that lead to a functioning system before the attainment of the definitive...

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Published in:Birth defects research. Part C. Embryo today 2003-02, Vol.69 (1), p.58-72
Main Authors: Barnett, Joey V., Desgrosellier, Jay S.
Format: Article
Language:English
Subjects:
Activin Receptors - physiology
Animals
Chick Embryo
Endocardial Cushion Defects - embryology
Extracellular Matrix - physiology
Fetal Proteins - physiology
Gene Expression Regulation, Developmental
Growth Substances - physiology
Heart Septum - embryology
Heart Valves - abnormalities
Heart Valves - embryology
Humans
Macromolecular Substances
Mesoderm - cytology
Mesoderm - physiology
Mice
Mice, Knockout
Morphogenesis - physiology
Receptors, Growth Factor - physiology
Signal Transduction - physiology
Transcription Factors - physiology
Transforming Growth Factor beta - physiology
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Summary:The proper formation and function of the vertebrate heart requires a multitude of specific cell and tissue interactions. These interactions drive the early specification and assembly of components of the cardiovascular system that lead to a functioning system before the attainment of the definitive cardiac and vascular structures seen in the adult. Many of these adult structures are hypothesized to require both proper molecular and physical cues to form correctly. Unlike any other organ system in the embryo, the cardiovascular system requires concurrent function and formation for the embryo to survive. An example of this complex interaction between molecular and physical cues is the formation of the valves of the heart. Both molecular cues that regulate cell transformation, migration, and extracellular matrix deposition, and physical cues emanating from the beating heart, as well as hemodynamic forces, are required for valvulogenesis. This review will focus on molecules and emerging pathways that guide early events in valvulogenesis. Birth Defects Research (Part C) 69:58–72, 2003. © 2003 Wiley‐Liss, Inc.
ISSN:1542-975X
1542-9768
DOI:10.1002/bdrc.10006