New Paradigm for Optical Imaging: Temporally Encoded Maps of Intrinsic Signal

We present a new technique for acquiring and analyzing intrinsic signal optical images of brain activity, using continuous stimulus presentation and data acquisition. The main idea is to present a temporally periodic stimulus and to analyze the component of the response at the stimulus frequency. Ad...

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Bibliographic Details
Published in:Neuron (Cambridge, Mass.) Mass.), 2003-05, Vol.38 (4), p.529-545
Main Authors: Kalatsky, Valery A., Stryker, Michael P.
Format: Article
Language:English
Subjects:
Animals
Brain
Brain Mapping - methods
Cameras
Cats
Cerebrovascular Circulation
Evoked Potentials, Visual - physiology
Functional Laterality - physiology
Mice
Mice, Inbred C3H
Mice, Inbred C57BL
Neurons - physiology
Neurosciences
Noise
Orientation - physiology
Photic Stimulation - methods
Reproducibility of Results
Software
Visual Cortex - blood supply
Visual Cortex - cytology
Visual Cortex - physiology
Visual Perception - physiology
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Summary:We present a new technique for acquiring and analyzing intrinsic signal optical images of brain activity, using continuous stimulus presentation and data acquisition. The main idea is to present a temporally periodic stimulus and to analyze the component of the response at the stimulus frequency. Advantages of the new technique include the removal of heart, respiration, and vasomotor artifacts, a dramatic increase in spatial resolution, and a 30-fold or greater reduction in acquisition time. We also present a novel approach to localizing instantaneous neuronal responses using time-reversed stimuli that is widely applicable to brain imaging. To demonstrate the power of the technique, we present high-resolution retinotopic maps of five visual areas in mouse cortex and orientation maps in cat visual cortex.
ISSN:0896-6273
1097-4199
DOI:10.1016/S0896-6273(03)00286-1