Linezolid-Resistant, Vancomycin-Resistant Enterococcus faecium Infection in Patients without Prior Exposure to Linezolid

We describe 2 patients without prior exposure to linezolid who were infected with closely related strains of linezolid- and vancomycin-resistant Enterococcus faecium (LRVREF) that may have been hospital acquired. Polymerase chain reaction amplification of the domain V region of the 23S ribosomal RNA...

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Bibliographic Details
Published in:Clinical infectious diseases 2003-06, Vol.36 (11), p.e146-e148
Main Authors: Rahim, Sibtain, Pillai, Satish K., Gold, Howard S., Venkataraman, Lata, Inglima, Kenneth, Press, Robert A.
Format: Article
Language:English
Subjects:
Acetamides - pharmacology
Aged
Cross Infection - transmission
Enterococcus faecium - drug effects
Enterococcus faecium - genetics
Female
Gram-Positive Bacterial Infections - microbiology
Humans
Linezolid
Male
Microbial Sensitivity Tests
Oxazolidinones - pharmacology
Point Mutation
RNA, Ribosomal, 23S - genetics
Vancomycin - pharmacology
Vancomycin Resistance - genetics
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Summary:We describe 2 patients without prior exposure to linezolid who were infected with closely related strains of linezolid- and vancomycin-resistant Enterococcus faecium (LRVREF) that may have been hospital acquired. Polymerase chain reaction amplification of the domain V region of the 23S ribosomal RNA gene demonstrated the presence of the G2576U mutation previously reported to be associated with linezolid resistance. Nosocomial transmission of LRVREF is an ominous sign and underscores the importance of meticulous infection-control measures.
ISSN:1058-4838
1537-6591
DOI:10.1086/374929