Loading…

Can patient-, treatment- and pathology-related characteristics explain the high local recurrence rate following breast-conserving therapy in young patients?

The aim of this study was to identify patient-, tumour- or treatment-related factors associated with young age that might explain the higher risk of ipsilateral breast recurrence that occurs after breast-conserving therapy (BCT) in young breast cancer patients. In the ‘boost versus no boost trial’,...

Full description

Saved in:
Bibliographic Details
Published in:European journal of cancer (1990) 2003-05, Vol.39 (7), p.932-944
Main Authors: Vrieling, C, Collette, L, Fourquet, A, Hoogenraad, W.J, Horiot, J.-C, Jager, J.J, Bing Oei, S, Peterse, H.L, Pierart, M, Poortmans, P.M, Struikmans, H, Van den Bogaert, W, Bartelink, H
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The aim of this study was to identify patient-, tumour- or treatment-related factors associated with young age that might explain the higher risk of ipsilateral breast recurrence that occurs after breast-conserving therapy (BCT) in young breast cancer patients. In the ‘boost versus no boost trial’, 5569 early-stage breast cancer patients were entered. All patients underwent tumorectomy followed by whole breast irradiation of 50 Gy. Patients having a microscopically complete excision were randomised between receiving no boost or a 16-Gy boost, while patients with a microscopically incomplete excision were randomised between receiving a boost dose of 10 or 26 Gy. The 5-year local control rate was 82% for patients ⩽35 years, 85% for patients aged 36–40 years, 92% for patients 41–50 years, 96% for patients 51–60 years and 97% for patients >60 years of age (P
ISSN:0959-8049
1879-0852
DOI:10.1016/S0959-8049(03)00123-0