Virological kinetics and immunological responses to a porcine reproductive and respiratory syndrome virus infection of pigs at different ages

The objective of this study was to measure the effect of two variables (pig age and virus strain) on selected responses (clinical signs, viraemia, virus excretion and seroconversion) of pigs following exposure to porcine reproductive and respiratory syndrome (PRRS) virus. Therefore, young (6 till 8...

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Bibliographic Details
Published in:Vaccine 2003-05, Vol.21 (17), p.1952-1957
Main Authors: van der Linden, I.F.A, Voermans, J.J.M, van der Linde-Bril, E.M, Bianchi, A.T.J, Steverink, P.J.G.M
Format: Article
Language:English
Subjects:
Age
Aging - immunology
Animals
Antibodies, Viral - blood
Antibody Formation
Biological and medical sciences
Experimental viral diseases and models
Experiments
Hogs
Immunization
Infections
Infectious diseases
Medical sciences
Palatine Tonsil - virology
Porcine Reproductive and Respiratory Syndrome - blood
Porcine Reproductive and Respiratory Syndrome - immunology
Porcine Reproductive and Respiratory Syndrome - physiopathology
Porcine respiratory and reproductive syndrome virus
Porcine respiratory and reproductive syndrome virus - immunology
Porcine respiratory and reproductive syndrome virus - isolation & purification
Porcine respiratory and reproductive syndrome virus - physiology
PRRSV
Strain
Swine
Viral diseases
Viremia - immunology
Viremia - physiopathology
Virus Replication
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Summary:The objective of this study was to measure the effect of two variables (pig age and virus strain) on selected responses (clinical signs, viraemia, virus excretion and seroconversion) of pigs following exposure to porcine reproductive and respiratory syndrome (PRRS) virus. Therefore, young (6 till 8 weeks old) and old (6 months old) pigs were infected with 3 different PRRSV strains, i.e. LV ter Huurne (LVTH), LV4.2.1 and SDSU#73. Regardless of the strain used for exposure, young pigs were more susceptible to infection as shown by a higher number of viraemic and virus excreting pigs. Strain differences were also evident. LV ter Huurne induced virus excretion in a higher number of pigs and with a higher virus titre, whereas SDSU#73 induced most severe clinical signs. LV4.2.1 induced viraemia and virus excretion in a low number of pigs. The kinetics of the antibody response differed per virus strain. The results presented here are useful in developing a less expensive standardised infection model, consisting of young pigs intranasally infected with a virulent PRRSV strain, to study the efficacy of new vaccine strains.
ISSN:0264-410X
1873-2518
DOI:10.1016/S0264-410X(02)00822-8