CD34+ cells from first-trimester fetal blood are enriched in primitive hemopoietic progenitors

Objective: The purpose of this study was to investigate whether purified CD34+ cells from first-trimester fetal blood are a source of primitive and committed hemopoietic progenitors. Study Design: CD34+ cells from first-trimester fetal blood and term cord blood were assayed for committed hemopoietic...

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Bibliographic Details
Published in:American journal of obstetrics and gynecology 2003-04, Vol.188 (4), p.1002-1010
Main Authors: Tocci, Angelo, Roberts, Irene A.G., Kumar, Sailesh, Bennett, Phillip R., Fisk, Nicholas M.
Format: Article
Language:English
Subjects:
Antigens, CD34 - analysis
Biological and medical sciences
Blood Cells - cytology
Blood Cells - immunology
Cells, Cultured
Colony-Forming Units Assay
Diseases of mother, fetus and pregnancy
Female
Fetal Blood
gene therapy
Gynecology. Andrology. Obstetrics
Hematopoietic Stem Cells - cytology
Hemopoietic progenitors
Humans
Medical sciences
Pregnancy
Pregnancy Trimester, First
Pregnancy. Fetus. Placenta
Time Factors
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Summary:Objective: The purpose of this study was to investigate whether purified CD34+ cells from first-trimester fetal blood are a source of primitive and committed hemopoietic progenitors. Study Design: CD34+ cells from first-trimester fetal blood and term cord blood were assayed for committed hemopoietic progenitor cells, high proliferative potential colony-forming cells, and long-term cultureinitiating cells. Results: First-trimester CD34+ cells that were compared with cells at term generated fewer hemopoietic progenitor cells and fewer high proliferative potential colony-forming cells with lower recloning efficiency (P
ISSN:0002-9378
1097-6868
DOI:10.1067/mob.2003.236