Frequencies of Circulating Cytolytic, CD45RA+CD27-, CD8+ T Lymphocytes Depend on Infection with CMV

Viral infections may cause serious disease unless the adaptive immune system is able to clear the viral agents through its effector arms. Recent identification and functional characterization of subpopulations of human CD8(+) T cells has set the stage to study the correlation between the appearance...

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Bibliographic Details
Published in:The Journal of immunology (1950) 2003-04, Vol.170 (8), p.4342-4348
Main Authors: Kuijpers, Taco W, Vossen, Mireille T, Gent, Mi-Ran, Davin, Jean-Claude, Roos, Marijke T, Wertheim-van Dillen, Pauline M, Weel, Jan F, Baars, Paul A, van Lier, Rene A
Format: Article
Language:English
Subjects:
Acute Disease
Adolescent
Aging - immunology
Antibodies, Viral - blood
Cell Division - immunology
Child
Child, Preschool
Cytomegalovirus - immunology
Cytomegalovirus - isolation & purification
Cytomegalovirus Infections - diagnosis
Cytomegalovirus Infections - immunology
Cytomegalovirus Infections - pathology
Cytomegalovirus Infections - virology
Cytotoxicity, Immunologic
Humans
Immunocompetence - immunology
Immunophenotyping
Infant
Leukocyte Common Antigens - biosynthesis
Lymphocyte Activation - immunology
Lymphocyte Count
Pedigree
Recurrence
T-Lymphocyte Subsets - immunology
T-Lymphocyte Subsets - metabolism
T-Lymphocyte Subsets - pathology
T-Lymphocyte Subsets - virology
T-Lymphocytes, Cytotoxic - immunology
T-Lymphocytes, Cytotoxic - metabolism
T-Lymphocytes, Cytotoxic - pathology
T-Lymphocytes, Cytotoxic - virology
Tumor Necrosis Factor Receptor Superfamily, Member 7 - biosynthesis
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Summary:Viral infections may cause serious disease unless the adaptive immune system is able to clear the viral agents through its effector arms. Recent identification and functional characterization of subpopulations of human CD8(+) T cells has set the stage to study the correlation between the appearance of particular subsets and common viral infections during childhood, i.e., EBV, CMV, varicella-zoster virus (VZV), and the attenuated measles-mumps-rubella (MMR) vaccine strains. In a cohort of 220 healthy children we analyzed lymphocytes and subpopulations of CD4(+) and CD8(+) T cells. The presence of the cytolytic CD45RA(+)CD27(-) subset of CD8(+) T cells correlated with prior CMV infection as defined by seroconversion (p < 0.0001). The number of this CD8(+) T cell subset remained stable during follow-up over 3 years in 40 children. The CD45RA(+)CD27(-) subset of CD8(+) T cells first appeared during acute CMV infection and subsequently stabilized at an individual set-point defined by age and immunocompetence. The functional importance of these cells in CMV surveillance was reflected by their increased numbers in immunosuppressed pediatric kidney transplant patients. Preferential expansion of CD8(+)CD45RA(+)CD27(-) cytolytic T cells seems unique for CMV.
ISSN:0022-1767
1550-6606
DOI:10.4049/jimmunol.170.8.4342