bantam Encodes a Developmentally Regulated microRNA that Controls Cell Proliferation and Regulates the Proapoptotic Gene hid in Drosophila

Cell proliferation, cell death, and pattern formation are coordinated in animal development. Although many proteins that control cell proliferation and apoptosis have been identified, the means by which these effectors are linked to the patterning machinery remain poorly understood. Here, we report...

Full description

Saved in:
Bibliographic Details
Published in:Cell 2003-04, Vol.113 (1), p.25-36
Main Authors: Brennecke, Julius, Hipfner, David R., Stark, Alexander, Russell, Robert B., Cohen, Stephen M.
Format: Article
Language:English
Subjects:
3' Untranslated Regions - genetics
Animals
Apoptosis - genetics
Base Sequence - genetics
Cell Division - genetics
Chromosome Mapping
Cyclins - genetics
Drosophila melanogaster - embryology
Drosophila melanogaster - genetics
Drosophila melanogaster - metabolism
Drosophila Proteins - genetics
Gene Expression Regulation, Developmental - genetics
Genes, Regulator - genetics
Larva - genetics
Larva - growth & development
MicroRNAs - genetics
Molecular Sequence Data
Mutation - genetics
Neuropeptides - genetics
Proto-Oncogene Proteins - genetics
Repressor Proteins - genetics
Wnt1 Protein
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Cell proliferation, cell death, and pattern formation are coordinated in animal development. Although many proteins that control cell proliferation and apoptosis have been identified, the means by which these effectors are linked to the patterning machinery remain poorly understood. Here, we report that the bantam gene of Drosophila encodes a 21 nucleotide microRNA that promotes tissue growth. bantam expression is temporally and spatially regulated in response to patterning cues. bantam microRNA simultaneously stimulates cell proliferation and prevents apoptosis. We identify the pro-apoptotic gene hid as a target for regulation by bantam miRNA, providing an explanation for bantam's anti-apoptotic activity.
ISSN:0092-8674
1097-4172
DOI:10.1016/S0092-8674(03)00231-9