Enterobactin: An Archetype for Microbial Iron Transport

Bacteria have aggressive acquisition processes for iron, an essential nutrient. Siderophores are small iron chelators that facilitate cellular iron transport. The siderophore enterobactin is a triscatechol derivative of a cyclic triserine lactone. Studies of the chemistry, regulation, synthesis, rec...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 2003-04, Vol.100 (7), p.3584-3588
Main Authors: Raymond, Kenneth N., Dertz, Emily A., Kim, Sanggoo S.
Format: Article
Language:English
Subjects:
Amides
Atoms
Bacteria - metabolism
Binding Sites
Biochemistry
Bioinorganic Chemistry Special Feature
Carrier proteins
Carrier Proteins - chemistry
Carrier Proteins - metabolism
Crystal structure
Enterobactin - chemistry
Enterobactin - metabolism
Iron
Iron - metabolism
Microbiology
Models, Molecular
Molecules
Protein Conformation
Protein Structure, Secondary
Proteins
Receptors
Siderophores
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Summary:Bacteria have aggressive acquisition processes for iron, an essential nutrient. Siderophores are small iron chelators that facilitate cellular iron transport. The siderophore enterobactin is a triscatechol derivative of a cyclic triserine lactone. Studies of the chemistry, regulation, synthesis, recognition, and transport of enterobactin make it perhaps the best understood of the siderophore-mediated iron uptake systems, displaying a lot of function packed into this small molecule. However, recent surprises include the isolation of corynebactin, a closely related trithreonine triscatechol derivative lactone first found in Gram-positive bacteria, and the crystal structure of a ferric enterobactin complex of a protein identified as an antibacterial component of the human innate immune system.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.0630018100