Homocysteine during the menstrual cycle in depressive women

Background Two possible factors that may have a causal relation with both depressive disorder and cardiovascular disease are elevated homocysteine and steroid hormones. Our previous study found significant changes in the plasma homocysteine concentration during the menstrual cycle in healthy women....

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Bibliographic Details
Published in:European journal of clinical investigation 2003-03, Vol.33 (3), p.268-273
Main Authors: Tallova, J., Bicikova, M., Hill, M., Tomandl, J., Valentova, D.
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Anxiety
Anxiety Disorders - blood
Anxiety Disorders - etiology
Biological and medical sciences
Chromatography, High Pressure Liquid - methods
Depression
Depressive Disorder - blood
Depressive Disorder - etiology
Estradiol - blood
Female
homocysteine
Homocystine - blood
Humans
Hydrocortisone - blood
Medical sciences
menstrual cycle
Menstrual Cycle - blood
Middle Aged
Mood disorders
Progesterone - blood
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
steroid hormones
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Summary:Background Two possible factors that may have a causal relation with both depressive disorder and cardiovascular disease are elevated homocysteine and steroid hormones. Our previous study found significant changes in the plasma homocysteine concentration during the menstrual cycle in healthy women. The purpose of this study therefore was to test homocysteine in depressive women treated with fluoxetine during the menstrual cycle. Materials and methods Thirteen premenopausal women suffering from mixed anxiety‐depressive disorder and a control group of 15 healthy women were enrolled in this study. The homocysteine concentration was determined by high‐performance liquid chromatography with fluorescence detection, and estradiol, progesterone and cortisol by RIA methods. Results We found significantly higher plasma homocysteine concentrations in the follicular phase than in the luteal phase of the menstrual cycle in both the depressive group (P 
ISSN:0014-2972
1365-2362
DOI:10.1046/j.1365-2362.2003.01087.x