Long-term treatment effect of atorvastatin on aortic stiffness in hypercholesterolaemic patients

Summary Aim: To assess the effect of atorvastatin on aortic stiffness in hypercholesterolaemic patients free of arterial hypertension and diabetes mellitus.Methods and Results: The study included 36 patients (25 men and 11 women, mean age 56 ± 12 years); 18 patients had stable coronary heart disease...

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Published in:Current medical research and opinion 2003, Vol.19 (1), p.22-27
Main Authors: Kontopoulos, Athanasios G., Athyros, Vasilios G., Pehlivanidis, Anthimos N., Demitriadis, Dimokritos S., Papageorgiou, Athanasios A., Boudoulas, Harisios
Format: Article
Language:English
Subjects:
Adult
Aged
Anticholesteremic Agents - administration & dosage
Anticholesteremic Agents - therapeutic use
Aorta
Aortic Valve - physiopathology
Atorvastatin
Biological and medical sciences
Cardiovascular Diseases - diagnosis
Cardiovascular Diseases - physiopathology
Echocardiography
Female
General and cellular metabolism. Vitamins
Heptanoic Acids - administration & dosage
Heptanoic Acids - therapeutic use
Humans
Hypercholesterolemia - drug therapy
Hypercholesterolemia - physiopathology
Male
Medical sciences
Middle Aged
Pharmacology. Drug treatments
Placebos
Pyrroles - administration & dosage
Pyrroles - therapeutic use
Stiffness
Time
United States
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Summary:Summary Aim: To assess the effect of atorvastatin on aortic stiffness in hypercholesterolaemic patients free of arterial hypertension and diabetes mellitus.Methods and Results: The study included 36 patients (25 men and 11 women, mean age 56 ± 12 years); 18 patients had stable coronary heart disease (CHD) and 18 were free of CHD at baseline. All patients received atorvastatin (20mg/day) for a 2-year period. Aortic stiffness was assessed by transthoracic echocardiography at baseline and 2 years later. At baseline, total cholesterol, low density lipoprotein cholesterol (LDL-C) and LDL-C/high density lipoprotein cholesterol (HDL-C) ratio were positively related to aortic stiffness (p 
ISSN:0300-7995
1473-4877
DOI:10.1185/030079902125001290