Methicillin-resistant Staphylococcus aureus in an adult military beneficiary population lacking risk factors: Susceptibility to orally available agents

To determine the unique susceptibility of community-acquired methicillin-resistant Staphylococcus aureus (MRSA) as a function of the presence or absence of risk factors in a military beneficiary population, we reviewed all MRSA cases between 1994 and 1997 in a military medical center. Of 67 cases, 2...

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Bibliographic Details
Published in:Military medicine 2003-02, Vol.168 (2), p.126-130
Main Authors: BAUM, Sue E, MORRIS, Joseph T, DOOLEY, David P, WATSON, Robert
Format: Article
Language:English
Subjects:
Administration, Oral
Adult
Anti-Bacterial Agents - administration & dosage
Antibiotics
Bacterial diseases
Biological and medical sciences
Cross Infection - drug therapy
Cross Infection - microbiology
Drug abuse
Human bacterial diseases
Humans
Infectious diseases
Medical sciences
Methicillin Resistance
Microbial Sensitivity Tests
Military Personnel
Patients
Risk Factors
Staphylococcal Infections - drug therapy
Staphylococcal Infections - microbiology
Staphylococcal infections, streptococcal infections, pneumococcal infections
Staphylococcus aureus - drug effects
Staphylococcus aureus - isolation & purification
Staphylococcus infections
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Summary:To determine the unique susceptibility of community-acquired methicillin-resistant Staphylococcus aureus (MRSA) as a function of the presence or absence of risk factors in a military beneficiary population, we reviewed all MRSA cases between 1994 and 1997 in a military medical center. Of 67 cases, 24 were community acquired, 9 of whom lacked risk factors for MRSA infection, and 43 cases were nosocomial. Among isolates from patients without risk factors, seven (77.8%) were susceptible to ciprofloxacin, eight (88.9%) to trimethoprim/sulfamethoxazole, eight (88.9%) to erythromycin, eight (88.9%) to tetracycline, and nine (100.0%) to clindamycin. These rates were markedly higher than those seen in isolates obtained from community-acquired cases with risk factors as well as from nosocomial cases (p < 0.01). Three clonal types of MRSA from patients without risk factors were identified and susceptibilities were similar for each of the three types. These results indicate that therapy with active oral agents might be reasonable for some less severe MRSA infections in our active duty military patients without risk factors, and additional studies are merited.
ISSN:0026-4075
1930-613X
DOI:10.1093/milmed/168.2.126