No evidence of association between prothrombotic gene polymorphisms and the development of acute myocardial infarction at a young age

We investigated the association between 9 polymorphisms of genes encoding hemostasis factors and myocardial infarction in a large sample of young patients chosen because they have less coronary atherosclerosis than older patients, and thus their disease is more likely to be related to a genetic pred...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 2003-03, Vol.107 (8), p.1117-1122
Main Author: Atherosclerosis, Thrombosis, and Vascular Biology Italian Study Group
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Cardiology. Vascular system
Case-Control Studies
Coronary heart disease
Female
Gene Frequency
Genetic Predisposition to Disease
Heart
Hemostasis - genetics
Humans
Male
Medical sciences
Myocardial Infarction - epidemiology
Myocardial Infarction - genetics
Polymorphism, Genetic
Risk Factors
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Summary:We investigated the association between 9 polymorphisms of genes encoding hemostasis factors and myocardial infarction in a large sample of young patients chosen because they have less coronary atherosclerosis than older patients, and thus their disease is more likely to be related to a genetic predisposition to a prothrombotic state. This nationwide case-control study involved 1210 patients who had survived a first myocardial infarction at an age of
ISSN:0009-7322
1524-4539
DOI:10.1161/01.CIR.0000051465.94572.D0