Remodeling of Gap Junctional Channel Function in Epicardial Border Zone of Healing Canine Infarcts

ABSTRACT—The epicardial border zone (EBZ) of canine infarcts has increased anisotropy because of transverse conduction slowing. It remains unknown whether changes in gap junctional conductance (Gj) accompany the increased anisotropy. Ventricular cell pairs were isolated from EBZ and normal hearts (N...

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Bibliographic Details
Published in:Circulation research 2003-03, Vol.92 (4), p.437-443
Main Authors: Yao, Jian-An, Hussain, Wajid, Patel, Pravina, Peters, Nicholas S, Boyden, Penelope A, Wit, Andrew L
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cardiology. Vascular system
Connexin 43 - analysis
Connexin 43 - physiology
Coronary heart disease
Dogs
Gap Junctions - physiology
Heart
Immunohistochemistry
Medical sciences
Membrane Potentials - physiology
Myocardial Infarction - pathology
Myocardial Infarction - physiopathology
Myocytes, Cardiac - chemistry
Myocytes, Cardiac - physiology
Pericardium - chemistry
Pericardium - pathology
Pericardium - physiopathology
Wound Healing
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Summary:ABSTRACT—The epicardial border zone (EBZ) of canine infarcts has increased anisotropy because of transverse conduction slowing. It remains unknown whether changes in gap junctional conductance (Gj) accompany the increased anisotropy. Ventricular cell pairs were isolated from EBZ and normal hearts (NZ). Dual patch clamp was used to quantify Gj. At a transjunctional voltage (Vj) of +10 mV, side-to-side Gj of EBZ pairs (9.2±3.4 nS, n=16) was reduced compared with NZ side-to-side Gj (109.4±23.6 nS, n=14, P
ISSN:0009-7330
1524-4571
DOI:10.1161/01.RES.0000059301.81035.06