Interferon-γ-inducible subunits are incorporated in human brain 20S proteasome

In most tissues expressing MHC class I molecules, proteasomes incorporating IFN-γ-inducible subunits, defined immuno-proteasomes, exist together with constitutive proteasomes. In physiological conditions, the central nervous system expresses neither MHC class I molecules nor TAP1 and TAP2 transporte...

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Bibliographic Details
Published in:Journal of neuroimmunology 2003-02, Vol.135 (1), p.135-140
Main Authors: Piccinini, Marco, Mostert, Michael, Croce, Sabrina, Baldovino, Simone, Papotti, Mauro, Rinaudo, Maria Teresa
Format: Article
Language:English
Subjects:
Antigen Presentation
Brain - enzymology
Human brain
Humans
IFN-γ-inducible subunits
Interferon-gamma - pharmacology
Kidney - enzymology
Molecular Weight
Multienzyme Complexes - metabolism
Peptide Hydrolases - metabolism
Proteasome
Proteasome Endopeptidase Complex
Protein Subunits
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Summary:In most tissues expressing MHC class I molecules, proteasomes incorporating IFN-γ-inducible subunits, defined immuno-proteasomes, exist together with constitutive proteasomes. In physiological conditions, the central nervous system expresses neither MHC class I molecules nor TAP1 and TAP2 transporters but besides being constitutive, it is unknown whether immuno-proteasomes are also present in this tissue. We present evidence that in human brain, the two types of proteasome exist suggesting that under physiological conditions, the mechanisms regulating expression of IFN-γ-inducible subunits as well as of MHC class I molecules and TAP1 and TAP2 transporters in nervous tissue, are not entirely coordinated.
ISSN:0165-5728
1872-8421
DOI:10.1016/S0165-5728(02)00439-3