Coordination of thiouridine monophosphates with selected metal ions

Potentiometric and spectroscopic data obtained for the complexes of two thio-substituted uridine-monophosphates with Cu 2+, Ni 2+ and Cd 2+ ions have shown that both thionucleotide are more effective ligands than their nucleoside analogues. The basic binding site for all metal ions is the sulfur ato...

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Bibliographic Details
Published in:Journal of inorganic biochemistry 2003-01, Vol.93 (3), p.119-124
Main Authors: Świa̧tek-Kozłowska, Jolanta, Brasuń, Justyna, Dobosz, Agnieszka, Sochacka, Elżbieta, Glowacka, Alicja
Format: Article
Language:English
Subjects:
Binding Sites
Cadmium - chemistry
Copper - chemistry
Hydrogen-Ion Concentration
Metal ions
Metals - chemistry
Molecular Structure
Nickel - chemistry
Nuclear Magnetic Resonance, Biomolecular
Potentiometry
Spectroscopy
Spectrum Analysis
Thiouridine - chemistry
Thiouridine monophosphates
Uracil Nucleotides - chemistry
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Summary:Potentiometric and spectroscopic data obtained for the complexes of two thio-substituted uridine-monophosphates with Cu 2+, Ni 2+ and Cd 2+ ions have shown that both thionucleotide are more effective ligands than their nucleoside analogues. The basic binding site for all metal ions is the sulfur atom. The chelation by adjacent N(3) donor is also likely, although unfavorable four-membered chelate ring is formed.
ISSN:0162-0134
1873-3344
DOI:10.1016/S0162-0134(02)00564-0