Hepatic amino‐acid metabolism in liver cirrhosis and in the long‐term course after liver transplantation

The aim of this study was to investigate the impact of orthotopic liver transplantation (OLT) on plasma levels and splanchnic turnover of key amino acids for muscular (branched‐chain amino acids: BCAAs) and hepatic metabolism (aromatic amino acids (AAAs) and methionine) in 48 patients with cirrhosis...

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Bibliographic Details
Published in:Transplant international 2003-01, Vol.16 (1), p.1-8
Main Authors: Tietge, Uwe J.F., Bahr, Matthias J., Manns, Michael P., Böker, Klaus H.W., Böker, K.H.W.
Format: Article
Language:English
Subjects:
Adult
Amino acids
Amino Acids, Aromatic - blood
Aromatic amino acids
Biological and medical sciences
Branched‐chain amino acids
Cirrhosis
Energy Metabolism
Female
Gastroenterology. Liver. Pancreas. Abdomen
Hepatic metabolism
Humans
Liver - blood supply
Liver - metabolism
Liver Circulation
Liver Cirrhosis - metabolism
Liver Cirrhosis - surgery
Liver Transplantation
Liver, biliary tract, pancreas, portal circulation, spleen
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Male
Medical sciences
Methionine
Methionine - blood
Middle Aged
Other diseases. Semiology
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the digestive system
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Summary:The aim of this study was to investigate the impact of orthotopic liver transplantation (OLT) on plasma levels and splanchnic turnover of key amino acids for muscular (branched‐chain amino acids: BCAAs) and hepatic metabolism (aromatic amino acids (AAAs) and methionine) in 48 patients with cirrhosis, 14 patients after OLT, and 46 controls. Also, hepatic amino‐acid supply and resting energy expenditure were measured. BCAA levels (no hepatic uptake) decreased in cirrhosis (P
ISSN:0934-0874
1432-2277
DOI:10.1111/j.1432-2277.2003.tb00215.x