bromodomain: a conserved sequence found in human, Drosophila and yeast proteins

Identification of conserved domains or motifs in proteins may aid in the localization and analysis of important structural and functional regions. We report here a protein sequence motif, called the bromodomain, that has been found in six genes from humans (CCG1 and RING3), Drosophila (fsh and brm),...

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Bibliographic Details
Published in:Nucleic acids research 1992-05, Vol.20 (10), p.2603-2603
Main Authors: Haynes, S.R, Dollard, C, Winston, F, Beck, S, Trowsdale, J, Dawid, I.B
Format: Article
Language:English
Subjects:
Amino Acid Sequence
amino acid sequences
Animals
Biochemistry & Molecular Biology
Biological and medical sciences
Consensus Sequence
DNA-Binding Proteins - chemistry
DNA-Binding Proteins - genetics
domains
Drosophila
Drosophila - genetics
Drosophila melanogaster
Fundamental and applied biological sciences. Psychology
Fungal Proteins - chemistry
Fungal Proteins - genetics
genbank/m23221
genbank/m23222
genbank/m55906
genbank/m80613
genbank/m85049
genbank/m87651
genbank/x07024
genes
Genes, Homeobox - genetics
Genes. Genome
helices
Humans
Life Sciences & Biomedicine
Molecular and cellular biology
Molecular genetics
Molecular Sequence Data
nucleotide sequences
Protein Conformation
proteins
Saccharomyces cerevisiae
Saccharomyces cerevisiae - genetics
Science & Technology
sequence homology
Transcription Factors - chemistry
Transcription Factors - genetics
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Summary:Identification of conserved domains or motifs in proteins may aid in the localization and analysis of important structural and functional regions. We report here a protein sequence motif, called the bromodomain, that has been found in six genes from humans (CCG1 and RING3), Drosophila (fsh and brm), and yeast (SPT7 and SNF2). The fsh and brm genes are required maternally for proper expression fo certain homeotic genes. The SPT7 and SNF2 genes of Saccharomyces cerevisiae encode transcriptional activators. The SNF2 and brm proteins have extensive sequence homology. It is not clear whether the two human genes are involved in processes. CCG1 is a DNA-binding protein that complements temperature sensitive mutations that cause cell cycle arrest in G1. The RING3 gene is a newly identified human gene of unknown function, mapping to the class II region of the human major histocompatibility locus, that has substantial homology to the fsh gene.
ISSN:0305-1048
1362-4962
DOI:10.1093/nar/20.10.2603