ACCENTUATED VAGAL ANTAGONISM OF BETA-ADRENERGIC EFFECTS ON VENTRICULAR REPOLARIZATION - EVIDENCE OF WEAKER ANTAGONISM IN HOSTILE TYPE-A MEN

Background. Prior research has suggested a weaker parasympathetic antagonism of sympathetic effects on the heart in type A (coronary-prone) men. To confirm this phenomenon and extend our understanding of it, we investigated the effects of prior muscarinic blockade on the electrocardiogram T wave and...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 1992-06, Vol.85 (6), p.2045-2053
Main Authors: FUKUDO, S, LANE, JD, ANDERSON, NB, KUHN, CM, SCHANBERG, SM, MCCOWN, N, MURANAKA, M, SUZUKI, J, WILLIAMS, RB
Format: Article
Language:English
Subjects:
Adult
Atropine - pharmacology
Biological and medical sciences
Cardiac & Cardiovascular Systems
Cardiology. Vascular system
Cardiovascular System & Cardiology
Coronary heart disease
Electrocardiography
Heart
Heart - innervation
Heart Rate - physiology
Hostility
Humans
Isoproterenol - pharmacology
Life Sciences & Biomedicine
Male
Medical sciences
Peripheral Vascular Disease
Premedication
Receptors, Adrenergic, beta - drug effects
Science & Technology
Sympathetic Nervous System - drug effects
Sympathetic Nervous System - physiology
Type A Personality
Vagus Nerve - physiology
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Summary:Background. Prior research has suggested a weaker parasympathetic antagonism of sympathetic effects on the heart in type A (coronary-prone) men. To confirm this phenomenon and extend our understanding of it, we investigated the effects of prior muscarinic blockade on the electrocardiogram T wave and other cardiovascular and neuroendocrine responses to isoproterenol in type A and type B (non-coronary-prone) men. Methods and Results. Responses to two 5-minute intravenous isoproterenol infusions (0.01-mu-g/kg/min and 0.02-mu-g/kg/min) were evaluated in six type A and six type B men after pretreatment with either dextrose placebo or atropine (1.2 mg). Atropine significantly potentiated T wave attenuation in the recovery period after isoproterenol infusion (0-30+/-0.07 mV) compared with placebo (0.54+/-0.09 mV, p
ISSN:0009-7322
1524-4539
DOI:10.1161/01.CIR.85.6.2045