Cutting Edge: Profile of Chemokine Receptor Expression on Human Plasma Cells Accounts for Their Efficient Recruitment to Target Tissues

We systematically examined the repertoire of chemokine receptors expressed by human plasma cells. Fresh bone marrow plasma cells and myeloma cells consistently expressed CXCR4, CXCR6, CCR10, and CCR3. Accordingly, plasma cells responded to their respective ligands in chemotaxis and very late Ag-4-de...

Full description

Saved in:
Bibliographic Details
Published in:The Journal of immunology (1950) 2003-02, Vol.170 (3), p.1136-1140
Main Authors: Nakayama, Takashi, Hieshima, Kunio, Izawa, Dai, Tatsumi, Youichi, Kanamaru, Akihisa, Yoshie, Osamu
Format: Article
Language:English
Subjects:
Adult
Bone Marrow Cells - immunology
Bone Marrow Cells - metabolism
Cell Adhesion - immunology
Cell Movement - immunology
Cells, Cultured
Chemokine CCL11
Chemokine CXCL12
Chemokine CXCL13
Chemokine CXCL16
Chemokines - biosynthesis
Chemokines, CC - metabolism
Chemokines, CC - physiology
Chemokines, CXC - biosynthesis
Chemokines, CXC - metabolism
Chemokines, CXC - physiology
Humans
Ligands
Membrane Proteins - biosynthesis
Membrane Proteins - metabolism
Membrane Proteins - physiology
Multiple Myeloma - immunology
Organ Specificity - immunology
Plasma Cells - immunology
Plasma Cells - metabolism
Plasma Cells - physiology
Receptors, CCR10
Receptors, CCR3
Receptors, Chemokine - biosynthesis
Receptors, Chemokine - metabolism
Receptors, CXCR4 - biosynthesis
Receptors, CXCR4 - metabolism
Receptors, CXCR6
Receptors, Cytokine - biosynthesis
Receptors, Cytokine - metabolism
Receptors, G-Protein-Coupled
Receptors, Immunologic
Receptors, Scavenger
Receptors, Virus
Stromal Cells - immunology
Stromal Cells - metabolism
Tumor Cells, Cultured
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We systematically examined the repertoire of chemokine receptors expressed by human plasma cells. Fresh bone marrow plasma cells and myeloma cells consistently expressed CXCR4, CXCR6, CCR10, and CCR3. Accordingly, plasma cells responded to their respective ligands in chemotaxis and very late Ag-4-dependent cell adhesion to fibronectin. Immobilized CXC chemokine ligand (CXCL)16, a novel transmembrane-type chemokine and CXCR6 ligand, also directly induced adhesion of plasma cells without requiring G(alpha i) signaling or divalent cations. Furthermore, we revealed consistent expression of CXCL12 (CXCR4 ligand), CXCL16 (CXCR6 ligand), and CC chemokine ligand 28 (CCR10 and CCR3 ligand) in tissues enriched with plasma cells including bone marrow, and constitutive expression of CXCL12, CXCL16, and CC chemokine ligand 28 by cultured human bone marrow stromal cells. Collectively, plasma cells are likely to be recruited to bone marrow and other target tissues via CXCR4, CXCR6, CCR10, and CCR3. CXCR6 may also contribute to tissue localization of plasma cells through its direct binding to membrane-anchored CXCL16.
ISSN:0022-1767
1550-6606
DOI:10.4049/jimmunol.170.3.1136