Endogenous Hormones and Carotid Atherosclerosis in Elderly Men

The aging process is characterized by a number of gradual changes in circulating hormone concentrations as well as a gradual increase in the degree of atherosclerosis. The authors studied whether serum hormone levels are related to atherosclerosis of the carotid artery in independently living, elder...

Full description

Saved in:
Bibliographic Details
Published in:American journal of epidemiology 2003-01, Vol.157 (1), p.25-31
Main Authors: van den Beld, A. W., Bots, M. L., Janssen, J. A. M. L. L., Pols, H. A. P., Lamberts, S. W. J., Grobbee, D. E.
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
aging
Aging - physiology
Arteriosclerosis - blood
Arteriosclerosis - diagnostic imaging
Arteriosclerosis - epidemiology
Arteriosclerosis - prevention & control
atherosclerosis
Atherosclerosis (general aspects, experimental research)
Biological and medical sciences
Blood and lymphatic vessels
Cardiology. Vascular system
cardiovascular diseases
Carotid Artery Diseases - blood
Carotid Artery Diseases - diagnostic imaging
Carotid Artery Diseases - epidemiology
Carotid Artery Diseases - prevention & control
Case-Control Studies
dehydroepiandrosterone
Dehydroepiandrosterone - blood
dehydroepiandrosterone sulfate
Dehydroepiandrosterone Sulfate - blood
DHEA
DHEAS
Estrone - blood
Estrone - physiology
hormones
Humans
IGF
IGFBP
IMT
insulin-like growth factor
insulin-like growth factor binding protein
Insulin-Like Growth Factor Binding Protein 1 - blood
Insulin-Like Growth Factor Binding Protein 2 - blood
Insulin-Like Growth Factor Binding Protein 3 - blood
Insulin-Like Growth Factor I - metabolism
Insulin-Like Growth Factor I - physiology
intima-media thickness
Leptin - blood
Linear Models
Male
Medical sciences
men
Netherlands
Prevalence
Risk Factors
standard error
Testosterone - blood
Testosterone - physiology
Tunica Media - diagnostic imaging
Ultrasonography
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The aging process is characterized by a number of gradual changes in circulating hormone concentrations as well as a gradual increase in the degree of atherosclerosis. The authors studied whether serum hormone levels are related to atherosclerosis of the carotid artery in independently living, elderly men. In 1996, 403 men (aged 73–94 years) were randomly selected from the general population of Zoetermeer, the Netherlands. Carotid artery intima-media thickness was determined. Serum concentrations of testosterone; estrone; estradiol; dehydroepiandrosterone and dehydroepiandrosterone sulfate; insulin-like growth factor I (IGF-I) (total and free) and its binding proteins IGFBP-1, IGFBP-2, and IGFBP-3; and leptin were measured. After the authors adjusted for age, serum testosterone, estrone, and free IGF-I were inversely related to intima-media thickness. The strength of these relations was as powerful in subjects with as in those without prevalent cardiovascular disease. Serum estradiol; dehydroepiandrosterone sulfate; total IGF-I, IGFBP-1, IGFBP-2, and IGFBP-3; and leptin showed no association. These findings suggest that endogenous testosterone, estrone, and free IGF-I levels may play a protective role in the development of atherosclerosis in aging men.
ISSN:0002-9262
1476-6256
0002-9262
DOI:10.1093/aje/kwf160