Preparation of Nanosized Drug Particles by the Coating of Inorganic Cores: Naproxen and Ketoprofen on Alumina

Nanosized alumina particles with modal diameters of 8 and 13 nm, respectively, were successfully coated by the adsorption of naproxen [(+)-6-methoxy-α-methyl-2-naphthalene acetic acid] and ketoprofen [α-methyl-3-(4-methylbenzoil) benzene acetic acid] in aqueous and ethanol solutions. The presence of...

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Bibliographic Details
Published in:Journal of colloid and interface science 2002-07, Vol.251 (2), p.284-287
Main Authors: Joguet, Laurent, Sondi, Ivan, Matijević, Egon
Format: Article
Language:English
Subjects:
adsorption of drugs
alumina, nanosized
Aluminum Oxide - chemistry
Biological and medical sciences
Chemistry
coatings of drugs
drugs
Exact sciences and technology
General and physical chemistry
General pharmacology
ketoprofen
Ketoprofen - chemistry
Medical sciences
Nanoparticles - chemistry
Naproxen - chemistry
naproxene
Pharmacology. Drug treatments
Physicochemical properties. Structure-activity relationships
Solid-liquid interface
Surface physical chemistry
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Description
Summary:Nanosized alumina particles with modal diameters of 8 and 13 nm, respectively, were successfully coated by the adsorption of naproxen [(+)-6-methoxy-α-methyl-2-naphthalene acetic acid] and ketoprofen [α-methyl-3-(4-methylbenzoil) benzene acetic acid] in aqueous and ethanol solutions. The presence of the drugs at the alumina surface was confirmed by attenuated total reflection infrared spectroscopy and electrokinetic measurements, while their bound amounts were assessed by thermogravimetric analysis.
ISSN:0021-9797
1095-7103
DOI:10.1006/jcis.2002.8408