Expression of nuclear retinoic acid receptor in peripheral blood mononuclear cells (PBMC) of healthy subjects

In vertebrates, both nuclear all-trans and 9-cis retinoic acid receptors (RAR and RXR) belonging to the steroid/thyroid/retinoid nuclear receptor superfamily play a crucial role in the vitamin A action. Qualitative analysis of all known RAR or RXR subtypes in both pooled and non-pooled peripheral bl...

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Bibliographic Details
Published in:Life sciences (1973) 2003-01, Vol.72 (7), p.831-836
Main Authors: Szabova, L, Macejova, D, Dvorcakova, M, Mostbock, S, Blazickova, S, Zorad, S, Walrand, S, Cardinault, N, Vasson, M-P, Rock, E, Brtko, J
Format: Article
Language:English
Subjects:
9-cis retinoic acid receptors
All-trans retinoic acid receptors
Cell Nucleus - genetics
Cell Nucleus - metabolism
DNA Primers - chemistry
Electrophoresis, Agar Gel
Expression
Humans
Leukocytes, Mononuclear - metabolism
Peripheral blood mononuclear cells
Receptors, Retinoic Acid - classification
Receptors, Retinoic Acid - genetics
Receptors, Retinoic Acid - metabolism
Reverse Transcriptase Polymerase Chain Reaction
RNA, Messenger - metabolism
RT–PCR
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Summary:In vertebrates, both nuclear all-trans and 9-cis retinoic acid receptors (RAR and RXR) belonging to the steroid/thyroid/retinoid nuclear receptor superfamily play a crucial role in the vitamin A action. Qualitative analysis of all known RAR or RXR subtypes in both pooled and non-pooled peripheral blood mononuclear cells (PBMC) from healthy human subjects has been performed by reverse transcription and polymerase chain reaction (RT–PCR). Our data, based on qualitative RT–PCR analysis has shown that human PBMC are capable to express RAR α, RAR γ, RXR α, and RXR β.
ISSN:0024-3205
1879-0631
DOI:10.1016/S0024-3205(02)02307-X