The differential expression of corticotropin releasing factor and its binding protein in the gerbil hippocampal complex following seizure

Considerable attention has been focused on the role of corticotropin releasing factor (CRF) as well as CRF-binding protein (CRF-BP) in neuropsychiatric disorders and neurodegenerative diseases including epilepsy. Therefore, in the present study, we investigated the temporal and spatial alteration of...

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Bibliographic Details
Published in:Neurochemistry international 2003-01, Vol.42 (1), p.57-65
Main Authors: Park, Seung-Kook, Choi, Dong-Il, Hwang, In-Koo, An, Sung-Jin, Suh, Jun-Gyo, Oh, Yang-Seok, Won, Moo Ho, Kang, Tae-Cheon
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Carrier Proteins - biosynthesis
Carrier Proteins - genetics
Corticotropin-Releasing Hormone - biosynthesis
Corticotropin-Releasing Hormone - genetics
Dentate gyrus
Entorhinal cortex
Entorhinal Cortex - metabolism
Epilepsy
Feedback
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation
Genetic Predisposition to Disease
Gerbillinae
Hippocampus
Hippocampus - metabolism
Interneurons - metabolism
Nerve Tissue Proteins - biosynthesis
Nerve Tissue Proteins - genetics
Physical Stimulation - adverse effects
RNA, Messenger - biosynthesis
Seizures - etiology
Seizures - genetics
Subiculum
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Summary:Considerable attention has been focused on the role of corticotropin releasing factor (CRF) as well as CRF-binding protein (CRF-BP) in neuropsychiatric disorders and neurodegenerative diseases including epilepsy. Therefore, in the present study, we investigated the temporal and spatial alteration of CRF and CRF-BP in the gerbil hippocampal complex in order to characterize the possible changes and associations with different sequelae of spontaneous seizure in these animals. CRF immunoreactivity was shown in the interneurons of the hippocampal complex at 30min following seizure. Additionally, alteration of CRF-BP immunoreactivity was restricted to the entorhinal cortex after seizure. These results indicate some factors for consideration. First, in the gerbil hippocampal complex, the delayed increase of CRF immunoreactivity, in spite of its excitatory function, may attenuate seizure activity, but may not do so in epileptogenesis. Second, in contrast to the hippocampl complex, the increase in CRF-BP immunoreactivity in the entorhinal cortex following seizure may participate in feedback inhibitory modulation.
ISSN:0197-0186
1872-9754
DOI:10.1016/S0197-0186(02)00060-8