Long-term effects of sometribove in lactating cows during a fourth consecutive lactation of treatment: insulin and somatotropin responses to glucose infusion

The effect of sometribove (USAN, methionyl bST) on the endocrine pancreas and blood bST concentrations was investigated in 6 control and 6 treated Friesian cows, averaging 111 and 118 d postpartum in their fourth lactation of treatment. Each lactation the treated cows received sometribove injections...

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Bibliographic Details
Published in:Journal of dairy science 1992-02, Vol.75 (2), p.472-480
Main Authors: Adriaens, F.A. (Monsanto, Basingstoke, England), Miller, M.A, Hard, D.L, Weller, R.F, Hale, M.D, Collier, R.J
Format: Article
Language:English
Subjects:
Animals
Blood Glucose - analysis
Cattle - physiology
COMPOSICION QUIMICA
COMPOSITION CHIMIQUE
CONTENIDO DE MATERIA SECA
ENSAYO
Female
FREQUENCE DU POULS
GLICEMIA
Glucose - administration & dosage
GLYCEMIE
Growth Hormone - analogs & derivatives
Growth Hormone - blood
Growth Hormone - pharmacology
HORMONAS PITUITARIAS
HORMONE HYPOPHYSAIRE
Human Growth Hormone
INGESTION DE PIENSO
Insulin - blood
Insulin - metabolism
Insulin Secretion
INSULINA
INSULINE
Islets of Langerhans - drug effects
Islets of Langerhans - metabolism
Lactation - drug effects
LAIT
LECHE
Milk - metabolism
NUMERO DE LACTACION
NUMERO DE LACTATION
PRISE ALIMENTAIRE (ANIMAUX)
PULSACIONES
Recombinant Proteins - pharmacology
RENDEMENT LAITIER
RENDIMIENTO LECHERO
SANG
SANGRE
TEMPERATURA DEL CUERPO
TEMPERATURE CORPORELLE
TENEUR EN MATIERE SECHE
TESTAGE
VACAS LECHERAS
VACHE LAITIERE
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Summary:The effect of sometribove (USAN, methionyl bST) on the endocrine pancreas and blood bST concentrations was investigated in 6 control and 6 treated Friesian cows, averaging 111 and 118 d postpartum in their fourth lactation of treatment. Each lactation the treated cows received sometribove injections (500 mg) every 2 wk (injection cycle) starting 60 +/- 3 d postpartum, increasing milk yield 3.3, 5.9. 1.9, and 4.2 kg/d in lactations 1, 2, 3, and 4, respectively. On d 8 of a fourth lactation injection cycle, blood was sampled for 390 min, starting 30 min before an intravenous glucose infusion (100 mg/kg) over a 20-min period. Preinfusion concentrations of glucose, insulin, md bST were elevated in sometribove-treated cows versus controls: 82.1 versus 74.4 mg/dl 28.1 versus 19.7 microIU/ml and 4.6 versus 0.9 ng/ml respectively. Glucose infusion resulted in a rapid increase in blood glucose and insulin concentrations, followed by a sharp decline to preinfusion values across both treatments, resulting in similar net area under the curves for glucose and insulin. Blood bST concentrations remained unchanged. This study supports the concept that sometribove increases milk yield in dairy cows by chronically influencing homeorhetic mechanisms
ISSN:0022-0302
1525-3198
DOI:10.3168/jds.S0022-0302(92)77783-2