Randomized prospective comparative study: short-term treatment with ciclopiroxolamine (cream and solution) versus boric acid in the treatment of otomycosis

Sixty‐four patients with symptomatic otomycosis (80 infected ears) confirmed by direct microscopy and culture were randomly treated for 1 week with ciclopiroxolamine cream 1% (group A, 20 infected ears, 17 patients), ciclopiroxolamine solution 1% (group B, 20 infected ears, 17 patients) and boric ac...

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Bibliographic Details
Published in:Mycoses 2002-10, Vol.45 (7-8), p.317-328
Main Authors: Del Palacio, A., Cuétara, M. S., López-Suso, M. J., Amor, E., Garau, M.
Format: Article
Language:English
Subjects:
Administration, Topical
Adolescent
Adult
Aged
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antifungal agents
Antifungal Agents - administration & dosage
Antifungal Agents - therapeutic use
antimycotic chemotherapy
Antimykotische Chemotherapie
Bacterial Infections - drug therapy
Bacterial Infections - microbiology
Biological and medical sciences
boric acid
Boric Acids - pharmacology
Boric Acids - therapeutic use
Borsäure
Ciclopiroxolamin
ciclopiroxolamine
Ear Diseases - drug therapy
Ear Diseases - microbiology
Ent and stomatologic mycoses
Female
Human mycoses
Humans
Infectious diseases
Male
Medical sciences
Middle Aged
Mycoses
Mycoses - drug therapy
Mycoses - microbiology
Otitis Externa - drug therapy
Otitis Externa - microbiology
Otomycosis
Otomykose
Pharmacology. Drug treatments
Prospective Studies
Pyridones - administration & dosage
Pyridones - therapeutic use
short-term topical treatment
Time Factors
Topische Kurzzeitbehandlung
Treatment Outcome
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Summary:Sixty‐four patients with symptomatic otomycosis (80 infected ears) confirmed by direct microscopy and culture were randomly treated for 1 week with ciclopiroxolamine cream 1% (group A, 20 infected ears, 17 patients), ciclopiroxolamine solution 1% (group B, 20 infected ears, 17 patients) and boric acid (group C, 40 infected ears, 30 patients) and daily mechanical suction aspiration of the debris. An attempt was made to match 11 clinical parameters with both the mycological and bacteriological findings. There was no significant association between the fungal species cultured and the clinical parameters did not vary with the presence or absence of different bacteria; pus was never present in fungal otitis externa (Fisher's test, P 
ISSN:0933-7407
1439-0507
DOI:10.1046/j.1439-0507.2002.00737.x