Common HLA-B8-DR3 haplotype in Northern India is different from that found in Europe

: The aim of this study was to determine whether a common diabetic haplotype, including human leukocyte antigen (HLA)‐B8 and HLA‐DR3, in Northern India is the same haplotype as the European HLA‐B8‐DR3 haplotype. DNA samples from Northern Indian subjects selected on the basis of HLA‐B8 and HLA‐DR3 we...

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Bibliographic Details
Published in:Tissue antigens 2002-12, Vol.60 (6), p.474-480
Main Authors: Witt, C.S., Price, P., Kaur, G., Cheong, K., Kanga, U., Sayer, D., Christiansen, F., Mehra, N.K.
Format: Article
Language:English
Subjects:
ancestral haplotype
Diabetes Mellitus, Type 1 - ethnology
Diabetes Mellitus, Type 1 - genetics
Europe - epidemiology
Genetic Predisposition to Disease - epidemiology
Haplotypes
HLA-B8 Antigen - genetics
HLA-DR3 Antigen - genetics
human leukocyte antigen
Humans
India
India - epidemiology
major histocompatibility complex
Microsatellite Repeats
Risk Factors
type 1 diabetes
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Summary:: The aim of this study was to determine whether a common diabetic haplotype, including human leukocyte antigen (HLA)‐B8 and HLA‐DR3, in Northern India is the same haplotype as the European HLA‐B8‐DR3 haplotype. DNA samples from Northern Indian subjects selected on the basis of HLA‐B8 and HLA‐DR3 were tested for microsatellite and single nucleotide polymorphism alleles throughout the major histocompatibility complex (MHC). It was found that the Indian samples represent a conserved haplotype in which all alleles were shared by Indian subjects with HLA‐B8 and HLA‐DR3, but were different to those that are characteristic of the European 8.1 ancestral haplotype. The Indian and European haplotypes share HLA‐B*0801, HLA‐DRB1*0301 and HLA‐DQB1*02 but differ for subtypes of HLA‐Cw*07 and HLA‐DRB3 and all central MHC alleles tested. In contrast, Indian subjects selected on the basis of HLA‐B58 ( 1–17) and HLA‐DR3 shared the same alleles at other MHC loci as have been described in the common Chinese haplotype with HLA‐B58/17 and HLA‐DR3. A third haplotype, HLA‐B50/21 and HLA‐DR3, was also found to be highly conserved but shares little in common with the other two HLA‐DR3‐containing Indian haplotypes.
ISSN:0001-2815
1399-0039
DOI:10.1034/j.1399-0039.2002.600602.x