Anti-Ri antibody positive opsoclonus-myoclonus in a male patient with breast carcinoma

A 65-year-old male patient developed truncal ataxia, opsoclonus and myoclonus. In the serum anti-Ri antibodies were found, which led to the detection of a small adenocarcinoma of the breast. Other prominent clinical features were an excessive startle response and behavioral disorders, such as anxiet...

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Bibliographic Details
Published in:Journal of neurology 2002-12, Vol.249 (12), p.1710-1712
Main Authors: WIRTZ, Paul W, SMITT, Peter A. E. Sillevis, HOFF, Jorrit I, DE LEEUW, Bertie, LAMMERS, Gert Jan, VAN DUINEN, Sjoerd G, VERSCHUUREN, Jan J
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Language:eng
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Summary:A 65-year-old male patient developed truncal ataxia, opsoclonus and myoclonus. In the serum anti-Ri antibodies were found, which led to the detection of a small adenocarcinoma of the breast. Other prominent clinical features were an excessive startle response and behavioral disorders, such as anxiety and impatience. These features suggest an immune response against both Nova-1 and Nova-2 antigens throughout the central nervous system.
ISSN:0340-5354
1432-1459