Modulation of renal sympathetic nerve activity during pneumoperitoneum in rats

To examine neural control of renal function during pneumoperitoneum, renal sympathetic nerve activity (RSNA) was measured in pentobarbital‐anesthetized rats that had their entire nervous system intact or that had undergone lower thoracic dorsal rhizotomy or abdominal vagotomy. During pneumoperitoneu...

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Bibliographic Details
Published in:World journal of surgery 2002-12, Vol.26 (12), p.1412-1417
Main Authors: Tanaka, Kunihiko, Tsuchiya, Yo, Ree, Ken, Morita, Hironobu
Format: Article
Language:English
Subjects:
Abdomen
Analysis of Variance
Animals
Biological and medical sciences
Central Venous Pressure
Disease Models, Animal
Gastroenterology. Liver. Pancreas. Abdomen
Glomerular Filtration Rate - physiology
Intraabdominal Pressure
Kidney - innervation
Kidney - physiology
Kidney Function Tests
Laparoscopy - adverse effects
Laparoscopy - methods
Male
Medical sciences
Miscellaneous
Neural Conduction
Other diseases. Semiology
Pneumoperitoneum, Artificial - adverse effects
Pneumoperitoneum, Artificial - methods
Probability
Random Allocation
Rats
Rats, Sprague-Dawley
Reference Values
Renal Blood Flow
Renal Circulation - physiology
Renal Denervation
Rhizotomy
Risk Assessment
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Sympathetic Nervous System - physiology
Urine Volume
Vagotomy
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Summary:To examine neural control of renal function during pneumoperitoneum, renal sympathetic nerve activity (RSNA) was measured in pentobarbital‐anesthetized rats that had their entire nervous system intact or that had undergone lower thoracic dorsal rhizotomy or abdominal vagotomy. During pneumoperitoneum with intraabdominal pressure (IAP) of 10 mmHg, the mean arterial pressure did not change, but central venous pressure increased by 10 mmHg in all groups. In intact rats, the RSNA increased to 285 ± 22% during pneumoperitoneum and gradually recovered after release of the insufflation. The RSNA responses decreased during pneumoperitoneum in rats with dorsal rhizotomy or vagotomy compared to responses in intact rats. In intact rats the urine volume and Na+ excretion decreased during pneumoperitoneum and increased just after insufflation release. Dorsal rhizotomy, vagotomy, or renal denervation did not alter the antidiuretic and antinatriuretic responses during pneumoperitoneum; however, diuretic and natriuretic responses were completely abolished by either of these denervations following insufflation release. These results suggest that oliguria during pneumoperitoneum was not due to neural control of renal function but probably to a mechanical influence induced by the elevated LAP. On the other hand, diuretic and natriuretic responses after insufflation release were thought to be a neurally mediated response. Résumé Afin d’évaluer le contrôle nerveux de la fonction rénale sous l’influence du pneumopéritoine, on a mesuré l’activité nerveuse sympathique rénale (RSNA) chez le rat anesthésié par pentobarbital que le système nerveux de l’animal soit intact, ou interrompu par une rhizotomie dorsothoracique basse ou par une vagotomie abdominale. Pendant le pneumopéritoine avec un pression intra‐abdominale (IAP) de 10 mm Hg, la pression artérielle moyenne n’a pas changé, mais la pression veineuse a augmenté de 10 mm Hg dans tous les groupes. Chez le rat à système nerveux intact, la RSNA a augmenté à 285 ± 22% pendant le pneumopéritoine et a progressivement retrouvé les valeurs normales après l’arrêt de l’insufflation. Les réponses RSNA étaient diminuées chez le rat ayant eu une rhizotomie dorsale ou une vagotomie comparées aux réponses de rats à système nerveux intact. Chez ces derniers, le volume urinaire et l’excrétion sodique ont diminué lors du pneumopéritoine et ont augmenté juste après l’arrêt de l’insufflation. Ni la réponse antidiurétique ni natriurétquie ont été
ISSN:0364-2313
1432-2323
DOI:10.1007/s00268-002-6447-9