Reactive nitrogen species and cell signaling: Implications for death or survival of lung epithelium

Reactive nitrogen species such as nitric oxide, peroxynitrite, and nitrogen dioxide have been implicated in the pathophysiology of inflammatory lung diseases. Yet, the molecular mechanisms and cell signaling events responsible for cellular injury remain to be elucidated. Two major signaling pathways...

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Bibliographic Details
Published in:American journal of respiratory and critical care medicine 2002-12, Vol.166 (12), p.S9-S16
Main Authors: JANSSEN-HEININGER, Yvonne M. W, PERSINGER, Rebecca L, KORN, Solange H, PANTANO, Cristen, MCELHINNEY, Brian, REYNAERT, Niki L, LANGEN, Ramon C. J, CKLESS, Karina, SHRIVASTAVA, Punya, POYNTER, Matthew E
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cell Death - physiology
Humans
Lung Diseases - metabolism
Lung Diseases - physiopathology
Medical sciences
Mitogen-Activated Protein Kinase Kinases - metabolism
Mitogen-Activated Protein Kinase Kinases - physiology
Pneumology
Reactive Nitrogen Species - metabolism
Reactive Nitrogen Species - physiology
Respiratory Mucosa - metabolism
Respiratory Mucosa - physiology
Respiratory system : syndromes and miscellaneous diseases
Signal Transduction - physiology
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Summary:Reactive nitrogen species such as nitric oxide, peroxynitrite, and nitrogen dioxide have been implicated in the pathophysiology of inflammatory lung diseases. Yet, the molecular mechanisms and cell signaling events responsible for cellular injury remain to be elucidated. Two major signaling pathways, co-ordinately regulated and responsible for cell survival and cell death, involve nuclear factor kappa B and c-Jun-N-terminal kinase, respectively. A review of these pathways, their modes of action, and their importance in executing oxidative stress responses in lung epithelial cells are discussed.
ISSN:1073-449X
1535-4970
DOI:10.1164/rccm.2206008