Interleukin-13 Receptor in Psoriatic Keratinocytes: Overexpression of the mRNA and Underexpression of the Protein

Although several cytokines and their receptors have been involved in the development of psoriasis, the etiology is still unknown. In this study we looked for genes possibly involved in the disease by the reverse transcription–polymerase chain reaction differential display technique in lesional and n...

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Bibliographic Details
Published in:Journal of investigative dermatology 2002-11, Vol.119 (5), p.1114-1120
Main Authors: Cancino-Díaz, Juan C., Reyes-Maldonado, Elba, Bañuelos-Pánuco, Carmen A., Jiménez-Zamudio, Luis, García-Latorre, Ethel, Cancino-Díaz, Mario E., León-Dorantes, Gladys, Blancas-González, Fernando, Paredes-Cabrera, Giovanna
Format: Article
Language:English
Subjects:
Arthritis, Psoriatic - pathology
Arthritis, Psoriatic - physiopathology
Biological and medical sciences
Biopsy
Dermatology
Gene Expression
Gene Expression Profiling
Humans
IL-13
Immunohistochemistry
Interleukin-13
Interleukin-13 - analysis
Interleukin-13 Receptor alpha1 Subunit
Interleukin-4 - analysis
Keratinocytes - chemistry
Keratinocytes - physiology
kerationocytes
Medical sciences
Psoriasis. Parapsoriasis. Lichen
receptor psoriasis
Receptors, Interleukin - analysis
Receptors, Interleukin - genetics
Receptors, Interleukin-13
Receptors, Interleukin-4 - analysis
Receptors, Interleukin-4 - genetics
Reverse Transcriptase Polymerase Chain Reaction
RNA, Messenger - analysis
Skin - physiopathology
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Summary:Although several cytokines and their receptors have been involved in the development of psoriasis, the etiology is still unknown. In this study we looked for genes possibly involved in the disease by the reverse transcription–polymerase chain reaction differential display technique in lesional and nonlesional skin biopsies from psoriatic patients. We found the mRNA of the α1 chain of the interleukin-13 receptor expressed differentially in psoriatic biopsies. By reverse transcription–polymerase chain reaction, we confirmed an overexpression of the α1 chain of the IL-13 receptor and α chain of the interleukin-4 receptor mRNA in lesional skin psoriatic biopsies, when compared with skin biopsies from healthy subjects (p
ISSN:0022-202X
1523-1747
DOI:10.1046/j.1523-1747.2002.19509.x