Genetics of ankylosing spondylitis

Ankylosing spondylitis is a common inflammatory rheumatic disease. Both susceptibility to and clinical manifestations of the disease are highly heritable. Although some genes, notably HLA-B27, have been implicated in susceptibility to the disease, the genetics of the condition are complex and many m...

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Bibliographic Details
Published in:	Clinical and experimental rheumatology 2002-11, Vol.20 (6), p.43-49
Main Authors:	BROWN, M. A, WORDSWORTH, B. P, REVEILLE, J. D
Format:	Article
Language:	eng
Subjects:	Biological and medical sciences Chromosome Mapping Diseases of the osteoarticular system HLA-B27 Antigen - genetics HLA-DR Antigens - genetics HLA-DRB1 Chains Humans Inflammatory joint diseases Major Histocompatibility Complex - genetics Medical sciences Severity of Illness Index Spondylitis, Ankylosing - genetics Spondylitis, Ankylosing - physiopathology
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Summary:	Ankylosing spondylitis is a common inflammatory rheumatic disease. Both susceptibility to and clinical manifestations of the disease are highly heritable. Although some genes, notably HLA-B27, have been implicated in susceptibility to the disease, the genetics of the condition are complex and many more genes involved in the condition await discovery.
ISSN:	0392-856X 1593-098X