Morphologic rather than functional or mechanical sonographic parameters of the brachial artery are related to angiographically evident coronary atherosclerosis

The purpose of this study was to determine the relationship among coronary atherosclerosis and functional, morphologic, and mechanical parameters assessed noninvasively within the brachial artery (BA). Flow-mediated vasodilation (FMD) of the BA, intima-media thickness (IMT) of the carotid artery, an...

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Bibliographic Details
Published in:Journal of the American College of Cardiology 2002-11, Vol.40 (10), p.1825-1830
Main Authors: Frick, Matthias, Schwarzacher, Severin P, Alber, Hannes F, Rinner, Alexander, Ulmer, Hanno, Pachinger, Otmar, Weidinger, Franz
Format: Article
Language:English
Subjects:
Adult
Age
Aged
Atherosclerosis
Biological and medical sciences
Blood pressure
Body mass index
Brachial Artery - diagnostic imaging
Brachial Artery - pathology
Cardiology
Cardiovascular disease
Cardiovascular system
Cholesterol
Confidence intervals
Coronary Angiography
Coronary Artery Disease - diagnosis
Coronary Artery Disease - epidemiology
Coronary Artery Disease - pathology
Coronary vessels
Diabetes
Family medical history
Hard disks
Humans
Hypertension
Investigative techniques, diagnostic techniques (general aspects)
Low density lipoprotein
Male
Mechanical properties
Medical imaging
Medical sciences
Middle Aged
Patients
Regression Analysis
Risk Factors
Statistics as Topic
Studies
Triglycerides
Tunica Intima - diagnostic imaging
Tunica Intima - pathology
Ultrasonic investigative techniques
Ultrasonography, Interventional
Vasodilation - physiology
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Summary:The purpose of this study was to determine the relationship among coronary atherosclerosis and functional, morphologic, and mechanical parameters assessed noninvasively within the brachial artery (BA). Flow-mediated vasodilation (FMD) of the BA, intima-media thickness (IMT) of the carotid artery, and distensibility of the aorta have been correlated with the presence of coronary artery disease (CAD). The BA was examined with high-resolution ultrasound (13 MHz) in 117 male patients, in whom coronary angiography was performed. Coronary artery disease (≥30% diameter stenosis in ≥1 major branch) was found in 84 patients, and 33 patients had smooth coronary arteries (non-CAD). Wall cross-sectional area (WCSA) was calculated from resting diameter and IMT. The BA-WCSA (5.3 ± 1.5 mm2vs. 4.4 ± 1.4 mm2, p = 0.002) and IMT (0.37 ± 0.07 mm vs. 0.31 ± 0.07 mm, p < 0.001) were significantly greater in patients with CAD compared with non-CAD patients. Flow-mediated vasodilation and distensibility were similar among groups. Using logistic regression analyses adjusting for age, positive family history, hypertension, hypercholesterolemia, smoking, FMD, and distensibility, only WCSA (p < 0.01) and IMT (p < 0.001) correlated independently with the presence of CAD. Morphologic but not functional and mechanical parameters of the BA are associated with the presence of CAD. Among BA sonographic parameters, IMT and WCSA seem to be the most accurate ones for the estimation of coronary atherosclerotic risk.
ISSN:0735-1097
1558-3597
DOI:10.1016/S0735-1097(02)02480-4