Homocysteine, cardiovascular disease risk factors, and habitual diet in the French Supplementation with Antioxidant Vitamins and Minerals Study

Background: An elevated plasma total homocysteine (tHcy) concentration seems to increase the risk of cardiovascular disease. Objective: We evaluated the determinants of tHcy in healthy French adults. Design: tHcy was measured by HPLC and fluorometric detection in 1139 women and 931 men aged 35-60 ga...

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Published in:The American journal of clinical nutrition 2002-12, Vol.76 (6), p.1279-1289
Main Authors: Mennen, Louise I, Courcy,Geneviève Potier de, Guilland, Jean-Claude, Ducros, Véronique, Bertrais, Sandrine, Nicolas, Jean-Pierre, Maurel, Michèle, Zarebska, Marjorie, Favier, Alain, Franchisseur, Claire, Hercberg, Serge, Galan, Pilar
Format: Article
Language:English
Subjects:
Adult
Aging
Alcohol Drinking
alcohols
antioxidant activity
Antioxidants
Antioxidants - administration & dosage
apolipoprotein B
Apolipoproteins B - blood
Biological and medical sciences
blood
Blood Glucose - analysis
blood pressure
Body Constitution
Body Mass Index
Cardiovascular disease
Cardiovascular Diseases - blood
Chromatography, High Pressure Liquid
chronic diseases
Coffee
Diet
dietary fiber
Dietary Fiber - administration & dosage
Dietary Supplements
Energy Intake
Erythrocytes - chemistry
Exercise
Fasting
Female
folic acid
Folic Acid - blood
France
glucose
Health risk assessment
high performance liquid chromatography
homocysteine
Homocysteine - blood
Human physiology applied to population studies and life conditions. Human ecophysiology
Humans
Male
Medical sciences
men
Middle Aged
Minerals
Minerals - administration & dosage
Nutritional survey. Food supply and nutritional requirement
physical activity
pyridoxine
Risk Factors
Sex Characteristics
Studies
triacylglycerols
Triglycerides - blood
Vitamin B 12 - blood
Vitamin B 6 - blood
vitamin B12
Vitamins
Vitamins - administration & dosage
women
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Summary:Background: An elevated plasma total homocysteine (tHcy) concentration seems to increase the risk of cardiovascular disease. Objective: We evaluated the determinants of tHcy in healthy French adults. Design: tHcy was measured by HPLC and fluorometric detection in 1139 women and 931 men aged 35-60 gamma. Subjects were participants of the Supplementation with Antioxidant Vitamins and Minerals Study, which investigates the effects of antioxidant supplementation on chronic diseases. Red blood cell folate (RBCF), plasma vitamins B-6 and B-12, and cardiovascular disease risk factors were also measured. The habitual diet was assessed in 616 subjects. Cross-sectional analyses were adjusted for age, smoking, energy intake, and concentration or intake of folate and vitamin B-6, where appropriate. Results: The mean (+/-SD) tHcy concentration was 8.74 +/- 2.71 μmol/L in women and 10.82 +/- 3.49 μmol/L in men. In women, tHcy was positively related to age (P = 0.001), apolipoprotein B (P < 0.01), serum triacylglycerol (P < 0.01), fasting glucose (P = 0.02), and coffee and alcohol consumption (both P < 0.01) and inversely related to RBCF (P = 0.11) and plasma vitamin B-12 (P = 0.08) and vitamin B-6 (P = 0.01) intakes. In men, tHcy was positively associated with body mass index (P = 0.03), blood pressure (P < 0.02), serum triacylglycerol (P < 0.01), fasting glucose (P = 0.01), and energy intake (P < 0.01) and inversely associated with physical activity (P = 0.04), RCBF (P = 0.02), plasma vitamin B-12 (P = 0.09), and dietary fiber (P < 0.01), folate (P = 0.03), and vitamin B-6 (P = 0.09) intakes. Conclusion: To control tHcy, decreasing coffee and alcohol consumption may be important in women, whereas increasing physical activity, dietary fiber, and folate intake may be important in men.
ISSN:0002-9165
1938-3207
DOI:10.1093/ajcn/76.6.1279