Antigenicity and immunogenicity of Melan-A/MART-1 derived peptides as targets for tumor reactive CTL in human melanoma

Some cancer patients mount spontaneous T‐ and B‐cell responses against their tumor cells. Autologous tumor reactive CD8 cytolytic T lymphocyte (CTL) and CD4 T‐cell clones as well as antibodies from these patients have been used for the identification of genes encoding the target antigens. This knowl...

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Published in:Immunological reviews 2002-10, Vol.188 (1), p.81-96
Main Authors: Romero, Pedro, Valmori, Danila, Pittet, Mikael J., Zippelius, Alfred, Rimoldi, Donata, Lévy, Frederic, Dutoit, Valérie, Ayyoub, Maha, Rubio-Godoy, Verena, Michielin, Olivier, Guillaume, Philippe, Batard, Pascal, Luescher, Immanuel F., Lejeune, Ferdy, Liénard, Danielle, Rufer, Nathalie, Dietrich, Pierre-Yves, Speiser, Daniel E., Cerottini, Jean-Charles
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Antigen Presentation
Antigens, Neoplasm - chemistry
Antigens, Neoplasm - immunology
Antineoplastic agents
Biological and medical sciences
Cancer Vaccines - immunology
Cancer Vaccines - therapeutic use
Cytotoxicity, Immunologic
Epitopes, T-Lymphocyte - immunology
HLA-A2 Antigen - immunology
Host-tumor relations. Immunology. Biological markers
Humans
Immunity, Innate
Immunotherapy
Immunotherapy, Active
MART-1 Antigen
Medical sciences
Melanoma - immunology
Melanoma - secondary
Melanoma - therapy
Molecular Sequence Data
Neoplasm Proteins - chemistry
Neoplasm Proteins - immunology
Peptide Fragments - immunology
Pharmacology. Drug treatments
Protein Interaction Mapping
Receptors, Antigen, T-Cell - immunology
Structure-Activity Relationship
T-Lymphocytes, Cytotoxic - immunology
Treatment Outcome
Tumors
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Summary:Some cancer patients mount spontaneous T‐ and B‐cell responses against their tumor cells. Autologous tumor reactive CD8 cytolytic T lymphocyte (CTL) and CD4 T‐cell clones as well as antibodies from these patients have been used for the identification of genes encoding the target antigens. This knowledge opened the way for new approaches to the immunotherapy of cancer. In this review, we describe the characterization of the structure‐function properties of the melanocyte/melanoma tumor antigen Melan‐A/MART‐1, the assessment of the T‐cell repertoire available against this antigen in healthy individuals, and the analysis of naturally acquired and/or vaccine‐induced CTL responses to this antigen in patients with metastatic melanoma.
ISSN:0105-2896
1600-065X
DOI:10.1034/j.1600-065X.2002.18808.x