Effects of exogenous LH administration during ovarian stimulation of pituitary down-regulated young oocyte donors on oocyte yield and developmental competence

BACKGROUND: The role of exogenous LH supplementation in ovarian stimulation is a matter of debate. Here we evaluate the impact of exogenous LH on oocyte yield and developmental competence in an oocyte donation programme. METHODS: Oocyte donors were randomized (computer-generated randomization list)...

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Bibliographic Details
Published in:Human reproduction (Oxford) 2002-12, Vol.17 (12), p.3129-3137
Main Authors: Tesarik, Jan, Mendoza, Carmen
Format: Article
Language:English
Subjects:
Adult
Aspirin - administration & dosage
Biological and medical sciences
Birth control
Cell Count
Embryo Implantation
Embryo Transfer
Embryo, Mammalian - anatomy & histology
Estradiol - administration & dosage
Estradiol - analogs & derivatives
Estradiol - blood
Female
Follicle Stimulating Hormone - administration & dosage
Gynecology. Andrology. Obstetrics
Humans
Luteinizing Hormone - administration & dosage
Male
Medical sciences
Middle Aged
oocyte developmental competence
Oocyte Donation
Oocytes
ovarian stimulation
Ovulation Induction
pituitary down-regulation
Pregnancy
Sperm Injections, Intracytoplasmic
Sterility. Assisted procreation
Zygote
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Summary:BACKGROUND: The role of exogenous LH supplementation in ovarian stimulation is a matter of debate. Here we evaluate the impact of exogenous LH on oocyte yield and developmental competence in an oocyte donation programme. METHODS: Oocyte donors were randomized (computer-generated randomization list) to groups stimulated with FSH alone or with a combination of FSH and LH after pituitary down-regulation with a GnRH agonist administered in the mid-luteal phase. RESULTS: In donors with deep suppression of pituitary LH (
ISSN:0268-1161
1460-2350
1460-2350
DOI:10.1093/humrep/17.12.3129