Analysis of allogeneic versus xenogeneic auxiliary organ perfusion in liver failure reveals superior efficacy of human livers

To compare the efficacy of allogeneic and xenogeneic extracorporeal liver perfusion (ECLP). An Internet-based keyword search was performed in the established online databases. Univariate and multivariate analysis of variance (general linear method) were performed. Data from 198 patients were include...

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Bibliographic Details
Published in:International journal of artificial organs 2002-10, Vol.25 (10), p.1006-1012
Main Authors: Pascher, A, Sauer, I M, Neuhaus, P
Format: Article
Language:English
Subjects:
Animals
Extracorporeal Circulation
Humans
Liver Circulation
Liver Failure, Acute - therapy
Liver, Artificial
Papio
Perfusion
Swine
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Summary:To compare the efficacy of allogeneic and xenogeneic extracorporeal liver perfusion (ECLP). An Internet-based keyword search was performed in the established online databases. Univariate and multivariate analysis of variance (general linear method) were performed. Data from 198 patients were included in the statistical analysis, 142 of whom were treated by ECLP using porcine livers. Baboon livers were used in 29 patients, human livers in 14, and other or mixed species in 13 patients. Pig liver perfusions resulted in a 20% long-term-survival whereas the use of human livers was significantly more successful (survival rate (SVR) 43%, p
ISSN:0391-3988
1724-6040
DOI:10.1177/039139880202501016