Gender-specific correlates of leptin with hypertension-related phenotypes in African Americans

Leptin may be a link in the relationship of obesity with hypertension. We evaluated associations of leptin with blood pressure (BP) in 54 normotensive and 114 hypertensive African American individuals. Plasma leptin was higher ( P < .03) in hypertensive women than in normotensive women, although...

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Bibliographic Details
Published in:American journal of hypertension 2002-11, Vol.15 (11), p.989-993
Main Authors: El-Gharbawy, Areeg H, Kotchen, Jane Morley, Grim, Clarance E, Kaldunski, Mary, Hoffmann, Raymond G, Pausova, Zdenka, Hamet, Pavel, Kotchen, Theodore A
Format: Article
Language:English
Subjects:
Adult
African American
African American, leptin, obesity-related hypertension
African Continental Ancestry Group
Arterial hypertension. Arterial hypotension
Biological and medical sciences
Blood and lymphatic vessels
Body Mass Index
Cardiology. Vascular system
Clinical manifestations. Epidemiology. Investigative techniques. Etiology
Female
Humans
Hypertension - blood
Hypertension - ethnology
Hypertension - physiopathology
Insulin - blood
leptin
Leptin - blood
Male
Medical sciences
Obesity - blood
Obesity - ethnology
Obesity - physiopathology
obesity-related hypertension
Sex Factors
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Summary:Leptin may be a link in the relationship of obesity with hypertension. We evaluated associations of leptin with blood pressure (BP) in 54 normotensive and 114 hypertensive African American individuals. Plasma leptin was higher ( P < .03) in hypertensive women than in normotensive women, although body mass index did not differ (30.5 ± 0.5 v 30.2 ± 0.8 kg/m 2). After adjusting for obesity and insulin resistance, there were no significant relationships between leptin and BP; however, leptin independently predicted 28% of the variability of heart rate in hypertensive men ( P < .01) and 18% of the variability of lithium clearance in hypertensive women ( P < .01). Thus, in these obese hypertensive African American women, there is no direct or independent association of leptin with BP. However, leptin may contribute to hypertension in these women by increasing renal tubular sodium reabsorption.
ISSN:0895-7061
1879-1905
1941-7225
DOI:10.1016/S0895-7061(02)03089-3