Transfollicular Drug Delivery: Penetration of Drugs Through Human Scalp Skin and Comparison of Penetration Between Scalp and Abdominal Skins In Vitro

In order to quantitatively investigate the importance of transfollicular pathway for drug delivery, drug penetration through human scalp skin was investigated using liquid formulations containing lipophilic and hydrophilic drugs in vitro. The penetration pathway for drugs through the scalp skin was...

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Bibliographic Details
Published in:Journal of drug targeting 2002, Vol.10 (5), p.369-378
Main Authors: Ogiso, Taro, Shiraki, Toshiya, Okajima, Kazuto, Tanino, Tadatoshi, Iwaki, Masahiro, Wada, Tetsuyuki
Format: Article
Language:English
Subjects:
Abdomen
Abdominal Skin Penetration
Acyclovir - administration & dosage
Acyclovir - pharmacokinetics
Administration, Cutaneous
Adult
Biological and medical sciences
Drug Delivery Systems
Female
Fluorouracil - administration & dosage
Fluorouracil - pharmacokinetics
General pharmacology
Hair Follicle - metabolism
Human Skin
Humans
In Vitro Techniques
Ketoprofen - administration & dosage
Ketoprofen - pharmacokinetics
Male
Medical sciences
Melatonin - administration & dosage
Melatonin - pharmacokinetics
Middle Aged
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Scalp
Scalp Skin Penetration
Skin Absorption
Transfollicular Drug Delivery
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Summary:In order to quantitatively investigate the importance of transfollicular pathway for drug delivery, drug penetration through human scalp skin was investigated using liquid formulations containing lipophilic and hydrophilic drugs in vitro. The penetration pathway for drugs through the scalp skin was examined using fluorescent probes. Additionally, the drug penetration through the scalp skin was compared with that via human abdominal skin to clarify the usefulness of intrafollicular delivery. Lipophilic melatonin (MT) and ketoprofen (KP) showed high permeabilities through the scalp skin, although the flux of KP was much higher. Absorption enhancers, N -methyl-2-pyrrolidone and isopropylmyristate, only slightly increased the fluxes. Hydrophilic fluorouracil (5FU) and acyclovir (ACV) penetrated through the scalp skin with relatively large fluxes. However, there was large variability in the fluxes of these drugs across scalp skin from different sources. When the relationship between the flux and hair follicle density was estimated, there was good correlation between the two (r =0.651 for MT and r =0.666 for ACV, P
ISSN:1061-186X
1029-2330
DOI:10.1080/1061186021000001814