Atrial compliance determines the nature of passive atrial stretch and plasma atrial natriuretic factor in the conscious dog

Study objective — The aim was to measure changes in atrial wall function over a wide range of atrial filling pressures in order to determine the relationship governing the atrial stretch in vivo. Design — Acute graded haemorrhage, 30 ml·kg−1, was used to reduce atrial stretch, and volume loading wit...

Full description

Saved in:
Bibliographic Details
Published in:Cardiovascular research 1991-09, Vol.25 (9), p.784-792
Main Authors: Stewart, Julian M, O'Dea, Daniel J, Shapiro, George C, Patel, Mrugesh B, McIntyre, John T, Gewitz, Michael H, Hoegler, Carl T, Shapiro, Jeffrey T, Zeballos, Guillermo A, Hintze, Thomas H
Format: Article
Language:English
Subjects:
A and V wave atrial compliance
Animals
Atrial Function - physiology
Atrial Natriuretic Factor - blood
atrial wall stress
Biological and medical sciences
Blood Volume - physiology
Dogs
exponential relationship
Fundamental and applied biological sciences. Psychology
haemorrhage
Hemorrhage - blood
Hemorrhage - physiopathology
right and left atrial appendages
Vertebrates: cardiovascular system
volume loading
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Study objective — The aim was to measure changes in atrial wall function over a wide range of atrial filling pressures in order to determine the relationship governing the atrial stretch in vivo. Design — Acute graded haemorrhage, 30 ml·kg−1, was used to reduce atrial stretch, and volume loading with 1000 ml saline was used to increase atrial stretch. Experimental material — Awake mongrel dogs (n=6) were instrumented for the measurement of left atrial appendage pressure and diameter; awake mongrel dogs (n=4) were instrumented for measurement of left and right atrial appendage pressures and diameters. Measurements and main results — During haemorrhage, left atrial pressure and diameter decreased progressively, and plasma atrial natriuretic factor fell from 44 (SEM 10) to 25(5) pg·ml−1 (p
ISSN:0008-6363
1755-3245
DOI:10.1093/cvr/25.9.784