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Antipyrine kinetics in undernourished diabetics
In developing countries diabetics frequently suffer from varying grades of malnutrition. The combined effect of malnutrition and non-insulin dependent diabetes (NIDDM) on the drug metabolising enzyme system has been evaluated using antipyrine as a protodrug. All the patients were under treatment and...
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| Published in: | European journal of clinical pharmacology 1991-01, Vol.41 (4), p.359-361 |
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| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c311t-c8a650e1a24fca92c90ab968119b5a48aec4982340d7e475e6edc461644f5a283 |
| container_end_page | 361 |
| container_issue | 4 |
| container_start_page | 359 |
| container_title | European journal of clinical pharmacology |
| container_volume | 41 |
| creator | SHOBBA, J. C RAGHURAM, T. C DEVA KUMAR, A KRISHNASWAMY, K |
| description | In developing countries diabetics frequently suffer from varying grades of malnutrition. The combined effect of malnutrition and non-insulin dependent diabetes (NIDDM) on the drug metabolising enzyme system has been evaluated using antipyrine as a protodrug. All the patients were under treatment and their plasma glucose values were within normal limits. The AUC of antipyrine was similar in all the groups. Although none of the kinetic parameters was altered in normal diabetics, the clearance of antipyrine was decreased and its half life was prolonged, with an increase in volume of distribution, in undernourished diabetics compared to undernourished controls. The results indicate that diabetes per se may not influence antipyrine kinetics when the blood glucose is well under control, but in the presence of undernutrition, it significantly alters the disposition of the drug. |
| doi_str_mv | 10.1007/BF00314968 |
| format | article |
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The results indicate that diabetes per se may not influence antipyrine kinetics when the blood glucose is well under control, but in the presence of undernutrition, it significantly alters the disposition of the drug.</description><identifier>ISSN: 0031-6970</identifier><identifier>EISSN: 1432-1041</identifier><identifier>DOI: 10.1007/BF00314968</identifier><identifier>PMID: 1804653</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Adult ; Analgesics ; Anthropometry ; Antipyrine - pharmacokinetics ; Biological and medical sciences ; Blood Glucose - metabolism ; Diabetes Mellitus, Type 2 - complications ; Diabetes Mellitus, Type 2 - metabolism ; Half-Life ; Humans ; India ; Male ; Medical sciences ; Metabolic Clearance Rate ; Microsomes, Liver - enzymology ; Middle Aged ; Neuropharmacology ; Nutrition Disorders - complications ; Nutrition Disorders - metabolism ; Pharmacology. 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C</creatorcontrib><creatorcontrib>RAGHURAM, T. C</creatorcontrib><creatorcontrib>DEVA KUMAR, A</creatorcontrib><creatorcontrib>KRISHNASWAMY, K</creatorcontrib><title>Antipyrine kinetics in undernourished diabetics</title><title>European journal of clinical pharmacology</title><addtitle>Eur J Clin Pharmacol</addtitle><description>In developing countries diabetics frequently suffer from varying grades of malnutrition. The combined effect of malnutrition and non-insulin dependent diabetes (NIDDM) on the drug metabolising enzyme system has been evaluated using antipyrine as a protodrug. All the patients were under treatment and their plasma glucose values were within normal limits. The AUC of antipyrine was similar in all the groups. Although none of the kinetic parameters was altered in normal diabetics, the clearance of antipyrine was decreased and its half life was prolonged, with an increase in volume of distribution, in undernourished diabetics compared to undernourished controls. The results indicate that diabetes per se may not influence antipyrine kinetics when the blood glucose is well under control, but in the presence of undernutrition, it significantly alters the disposition of the drug.</description><subject>Adult</subject><subject>Analgesics</subject><subject>Anthropometry</subject><subject>Antipyrine - pharmacokinetics</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - metabolism</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Diabetes Mellitus, Type 2 - metabolism</subject><subject>Half-Life</subject><subject>Humans</subject><subject>India</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabolic Clearance Rate</subject><subject>Microsomes, Liver - enzymology</subject><subject>Middle Aged</subject><subject>Neuropharmacology</subject><subject>Nutrition Disorders - complications</subject><subject>Nutrition Disorders - metabolism</subject><subject>Pharmacology. 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C</creator><creator>DEVA KUMAR, A</creator><creator>KRISHNASWAMY, K</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19910101</creationdate><title>Antipyrine kinetics in undernourished diabetics</title><author>SHOBBA, J. C ; RAGHURAM, T. C ; DEVA KUMAR, A ; KRISHNASWAMY, K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c311t-c8a650e1a24fca92c90ab968119b5a48aec4982340d7e475e6edc461644f5a283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Adult</topic><topic>Analgesics</topic><topic>Anthropometry</topic><topic>Antipyrine - pharmacokinetics</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose - metabolism</topic><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>Diabetes Mellitus, Type 2 - metabolism</topic><topic>Half-Life</topic><topic>Humans</topic><topic>India</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metabolic Clearance Rate</topic><topic>Microsomes, Liver - enzymology</topic><topic>Middle Aged</topic><topic>Neuropharmacology</topic><topic>Nutrition Disorders - complications</topic><topic>Nutrition Disorders - metabolism</topic><topic>Pharmacology. Drug treatments</topic><topic>Serum Albumin - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SHOBBA, J. C</creatorcontrib><creatorcontrib>RAGHURAM, T. C</creatorcontrib><creatorcontrib>DEVA KUMAR, A</creatorcontrib><creatorcontrib>KRISHNASWAMY, K</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of clinical pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SHOBBA, J. C</au><au>RAGHURAM, T. C</au><au>DEVA KUMAR, A</au><au>KRISHNASWAMY, K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antipyrine kinetics in undernourished diabetics</atitle><jtitle>European journal of clinical pharmacology</jtitle><addtitle>Eur J Clin Pharmacol</addtitle><date>1991-01-01</date><risdate>1991</risdate><volume>41</volume><issue>4</issue><spage>359</spage><epage>361</epage><pages>359-361</pages><issn>0031-6970</issn><eissn>1432-1041</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>In developing countries diabetics frequently suffer from varying grades of malnutrition. The combined effect of malnutrition and non-insulin dependent diabetes (NIDDM) on the drug metabolising enzyme system has been evaluated using antipyrine as a protodrug. All the patients were under treatment and their plasma glucose values were within normal limits. The AUC of antipyrine was similar in all the groups. Although none of the kinetic parameters was altered in normal diabetics, the clearance of antipyrine was decreased and its half life was prolonged, with an increase in volume of distribution, in undernourished diabetics compared to undernourished controls. The results indicate that diabetes per se may not influence antipyrine kinetics when the blood glucose is well under control, but in the presence of undernutrition, it significantly alters the disposition of the drug.</abstract><cop>Heidelberg</cop><cop>Berlin</cop><pub>Springer</pub><pmid>1804653</pmid><doi>10.1007/BF00314968</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0031-6970 |
| ispartof | European journal of clinical pharmacology, 1991-01, Vol.41 (4), p.359-361 |
| issn | 0031-6970 1432-1041 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72679708 |
| source | Springer Online Journal Archives |
| subjects | Adult Analgesics Anthropometry Antipyrine - pharmacokinetics Biological and medical sciences Blood Glucose - metabolism Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - metabolism Half-Life Humans India Male Medical sciences Metabolic Clearance Rate Microsomes, Liver - enzymology Middle Aged Neuropharmacology Nutrition Disorders - complications Nutrition Disorders - metabolism Pharmacology. Drug treatments Serum Albumin - metabolism |
| title | Antipyrine kinetics in undernourished diabetics |
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