Antipyrine kinetics in undernourished diabetics

In developing countries diabetics frequently suffer from varying grades of malnutrition. The combined effect of malnutrition and non-insulin dependent diabetes (NIDDM) on the drug metabolising enzyme system has been evaluated using antipyrine as a protodrug. All the patients were under treatment and...

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Bibliographic Details
Published in:European journal of clinical pharmacology 1991-01, Vol.41 (4), p.359-361
Main Authors: SHOBBA, J. C, RAGHURAM, T. C, DEVA KUMAR, A, KRISHNASWAMY, K
Format: Article
Language:English
Subjects:
Adult
Analgesics
Anthropometry
Antipyrine - pharmacokinetics
Biological and medical sciences
Blood Glucose - metabolism
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - metabolism
Half-Life
Humans
India
Male
Medical sciences
Metabolic Clearance Rate
Microsomes, Liver - enzymology
Middle Aged
Neuropharmacology
Nutrition Disorders - complications
Nutrition Disorders - metabolism
Pharmacology. Drug treatments
Serum Albumin - metabolism
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Summary:In developing countries diabetics frequently suffer from varying grades of malnutrition. The combined effect of malnutrition and non-insulin dependent diabetes (NIDDM) on the drug metabolising enzyme system has been evaluated using antipyrine as a protodrug. All the patients were under treatment and their plasma glucose values were within normal limits. The AUC of antipyrine was similar in all the groups. Although none of the kinetic parameters was altered in normal diabetics, the clearance of antipyrine was decreased and its half life was prolonged, with an increase in volume of distribution, in undernourished diabetics compared to undernourished controls. The results indicate that diabetes per se may not influence antipyrine kinetics when the blood glucose is well under control, but in the presence of undernutrition, it significantly alters the disposition of the drug.
ISSN:0031-6970
1432-1041
DOI:10.1007/BF00314968