Circadian heart rate variability in Parkinson's disease

Parkinson's disease is known to affect the reflex cardiovascular control systems, resulting in a suppressed heart rate variability, but present knowledge concerning the long-term characteristics of heart rate and heart rate variability, e. g. circadian regulation, is limited. We investigated th...

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Bibliographic Details
Published in:Journal of neurology 2002-11, Vol.249 (11), p.1535-1540
Main Authors: PURSIAINEN, Ville, HAAPANIEMI, Tarja H, KORPELAINEN, Juha T, HUIKURI, Heikki V, A.SOTANIEMI, Kyösti, MYLLYÄ, Vilho V
Format: Article
Language:English
Subjects:
Age Factors
Aged
Arrhythmias, Cardiac - etiology
Arrhythmias, Cardiac - physiopathology
Biological and medical sciences
Brain - physiopathology
Chronobiology Disorders - etiology
Chronobiology Disorders - physiopathology
Circadian Rhythm - physiology
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Disease Progression
Female
Heart Rate - physiology
Humans
Male
Medical sciences
Middle Aged
Neurology
Parasympathetic Nervous System - physiopathology
Parkinson Disease - complications
Parkinson Disease - physiopathology
Parkinson's disease
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Summary:Parkinson's disease is known to affect the reflex cardiovascular control systems, resulting in a suppressed heart rate variability, but present knowledge concerning the long-term characteristics of heart rate and heart rate variability, e. g. circadian regulation, is limited. We investigated the circadian fluctuation of the time domain, frequency domain and some non-linear measures of heart rate variability in 44 untreated patients with Parkinson's disease and 43 age- and sex-matched control subjects.In the parkinsonian patients, the measured power spectral components of heart rate variability (low-frequency power and high-frequency power) and the SD(1) value of the Poincaré two dimensional vector analysis, that quantifies the short term beat-to-beat variability, were suppressed at night. During the daytime only the SD1 of the Poincaré was suppressed. The night-to-day-ratios of the heart rate variability measures did not differ significantly between the patients and the controls. The results indicate that the long-term parasympathetic cardiovascular regulation is impaired in untreated patients with Parkinson's disease. The dysfunction is more pronounced at night.
ISSN:0340-5354
1432-1459
DOI:10.1007/s00415-002-0884-0