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Patterns of nutrient uptake by the mammary glands of lactating dairy cows
Twenty-one multiparous lactating dairy cows with previous 305-d milk production records varying from 5900 to 13,600 kg were used to examine patterns of nutrient uptake by the mammary glands. On d 71 and continuing until d 126 of lactation, animals were injected daily with 40 mg of sometribove (bST g...
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| Published in: | Journal of dairy science 1991-11, Vol.74 (11), p.3791-3799 |
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| cites | cdi_FETCH-LOGICAL-c475t-2af34a3fe630dd352aa449ea387ce7e866895b7ca7b0c48b39b1a893f0667a853 |
| container_end_page | 3799 |
| container_issue | 11 |
| container_start_page | 3791 |
| container_title | Journal of dairy science |
| container_volume | 74 |
| creator | Miller, P. S Reis, B. L Calvert, C. C DePeters, E. J Baldwin, R. L |
| description | Twenty-one multiparous lactating dairy cows with previous 305-d milk production records varying from 5900 to 13,600 kg were used to examine patterns of nutrient uptake by the mammary glands. On d 71 and continuing until d 126 of lactation, animals were injected daily with 40 mg of sometribove (bST group) or bicarbonate buffer (control group). Arterial and venous blood plasma samples were collected over a 12-h period on d 35, 70, 105, and 126 of lactation. Regression equations developed to evaluate linear effects of plasma arterial concentrations on net arterial-venous difference across the mammary glands demonstrated that, for acetate, NEFA, and D-beta-hydroxybutyrate, plasma arterial concentration accounted for over 50% of variation in uptake by the mammary glands. Additionally, a sigmoidal equation fitted the relationship between D-beta-hydroxybutyrate plasma arterial concentration and mammary gland uptake (r2 = 0.70). Triacylglyceride concentration was less effective in predicting uptake (r2 = 0.25). Administration of bST did not alter patterns of nutrient uptake, but a fourfold increase in NEFA uptake was predicted for bST-treated cows from this study, using NEFA concentrations from the literature. These observations indicate that plasma concentration of acetate, NEFA, D-beta-hydroxybutyrate, and triacylglyceride are major determinants of uptake by the mammary glands. Factors other than plasma concentration, such as mammary gland biosynthetic capacity, availability of other nutrients, and blood flow, determine uptakes of glucose, lactate, and total and free cholesterol (r2 less than or equal to 0.03). |
| doi_str_mv | 10.3168/jds.S0022-0302(91)78571-8 |
| format | article |
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S ; Reis, B. L ; Calvert, C. C ; DePeters, E. J ; Baldwin, R. L</creator><creatorcontrib>Miller, P. S ; Reis, B. L ; Calvert, C. C ; DePeters, E. J ; Baldwin, R. L ; University of Nebraska, Lincoln</creatorcontrib><description>Twenty-one multiparous lactating dairy cows with previous 305-d milk production records varying from 5900 to 13,600 kg were used to examine patterns of nutrient uptake by the mammary glands. On d 71 and continuing until d 126 of lactation, animals were injected daily with 40 mg of sometribove (bST group) or bicarbonate buffer (control group). Arterial and venous blood plasma samples were collected over a 12-h period on d 35, 70, 105, and 126 of lactation. Regression equations developed to evaluate linear effects of plasma arterial concentrations on net arterial-venous difference across the mammary glands demonstrated that, for acetate, NEFA, and D-beta-hydroxybutyrate, plasma arterial concentration accounted for over 50% of variation in uptake by the mammary glands. Additionally, a sigmoidal equation fitted the relationship between D-beta-hydroxybutyrate plasma arterial concentration and mammary gland uptake (r2 = 0.70). Triacylglyceride concentration was less effective in predicting uptake (r2 = 0.25). Administration of bST did not alter patterns of nutrient uptake, but a fourfold increase in NEFA uptake was predicted for bST-treated cows from this study, using NEFA concentrations from the literature. These observations indicate that plasma concentration of acetate, NEFA, D-beta-hydroxybutyrate, and triacylglyceride are major determinants of uptake by the mammary glands. Factors other than plasma concentration, such as mammary gland biosynthetic capacity, availability of other nutrients, and blood flow, determine uptakes of glucose, lactate, and total and free cholesterol (r2 less than or equal to 0.03).</description><identifier>ISSN: 0022-0302</identifier><identifier>EISSN: 1525-3198</identifier><identifier>DOI: 10.3168/jds.S0022-0302(91)78571-8</identifier><identifier>PMID: 1757621</identifier><identifier>CODEN: JDSCAE</identifier><language>eng</language><publisher>Savoy, IL: Am Dairy Sci Assoc</publisher><subject>3-Hydroxybutyric Acid ; absorcion de substancias nutritivas ; absorption de substances nutritives ; acetate ; acetates ; Acetates - metabolism ; acetatos ; acide gras ; acide lactique ; acido lactico ; acidos grasos ; Animals ; Biological and medical sciences ; Blood Glucose - metabolism ; blood plasma ; Cattle - physiology ; cholesterol ; Cholesterol - metabolism ; colesterol ; dairy cows ; fatty acids ; Fatty Acids, Nonesterified - metabolism ; Female ; forecasting ; Fundamental and applied biological sciences. Psychology ; General aspects ; glande mammaire ; glandulas mamarias ; glicemia ; glycaemia ; glycemie ; Growth Hormone - analogs & derivatives ; Growth Hormone - pharmacology ; hormonas pituitarias ; hormone hypophysaire ; Human Growth Hormone ; Hydroxybutyrates - metabolism ; Lactates - metabolism ; Lactation - physiology ; lactic acid ; mammary glands ; Mammary Glands, Animal - blood supply ; Mammary Glands, Animal - drug effects ; Mammary Glands, Animal - metabolism ; matematicas ; mathematics ; mathematique ; nutrient uptake ; pituitary hormones ; plasma sanguin ; plasma sanguineo ; Recombinant Proteins - pharmacology ; Regression Analysis ; technique de prevision ; tecnicas de prediccion ; trigliceridos ; triglyceride ; triglycerides ; Triglycerides - metabolism ; vacas lecheras ; vache laitiere ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>Journal of dairy science, 1991-11, Vol.74 (11), p.3791-3799</ispartof><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c475t-2af34a3fe630dd352aa449ea387ce7e866895b7ca7b0c48b39b1a893f0667a853</citedby><cites>FETCH-LOGICAL-c475t-2af34a3fe630dd352aa449ea387ce7e866895b7ca7b0c48b39b1a893f0667a853</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5125765$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1757621$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Miller, P. S</creatorcontrib><creatorcontrib>Reis, B. L</creatorcontrib><creatorcontrib>Calvert, C. C</creatorcontrib><creatorcontrib>DePeters, E. J</creatorcontrib><creatorcontrib>Baldwin, R. L</creatorcontrib><creatorcontrib>University of Nebraska, Lincoln</creatorcontrib><title>Patterns of nutrient uptake by the mammary glands of lactating dairy cows</title><title>Journal of dairy science</title><addtitle>J Dairy Sci</addtitle><description>Twenty-one multiparous lactating dairy cows with previous 305-d milk production records varying from 5900 to 13,600 kg were used to examine patterns of nutrient uptake by the mammary glands. On d 71 and continuing until d 126 of lactation, animals were injected daily with 40 mg of sometribove (bST group) or bicarbonate buffer (control group). Arterial and venous blood plasma samples were collected over a 12-h period on d 35, 70, 105, and 126 of lactation. Regression equations developed to evaluate linear effects of plasma arterial concentrations on net arterial-venous difference across the mammary glands demonstrated that, for acetate, NEFA, and D-beta-hydroxybutyrate, plasma arterial concentration accounted for over 50% of variation in uptake by the mammary glands. Additionally, a sigmoidal equation fitted the relationship between D-beta-hydroxybutyrate plasma arterial concentration and mammary gland uptake (r2 = 0.70). Triacylglyceride concentration was less effective in predicting uptake (r2 = 0.25). Administration of bST did not alter patterns of nutrient uptake, but a fourfold increase in NEFA uptake was predicted for bST-treated cows from this study, using NEFA concentrations from the literature. These observations indicate that plasma concentration of acetate, NEFA, D-beta-hydroxybutyrate, and triacylglyceride are major determinants of uptake by the mammary glands. Factors other than plasma concentration, such as mammary gland biosynthetic capacity, availability of other nutrients, and blood flow, determine uptakes of glucose, lactate, and total and free cholesterol (r2 less than or equal to 0.03).</description><subject>3-Hydroxybutyric Acid</subject><subject>absorcion de substancias nutritivas</subject><subject>absorption de substances nutritives</subject><subject>acetate</subject><subject>acetates</subject><subject>Acetates - metabolism</subject><subject>acetatos</subject><subject>acide gras</subject><subject>acide lactique</subject><subject>acido lactico</subject><subject>acidos grasos</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - metabolism</subject><subject>blood plasma</subject><subject>Cattle - physiology</subject><subject>cholesterol</subject><subject>Cholesterol - metabolism</subject><subject>colesterol</subject><subject>dairy cows</subject><subject>fatty acids</subject><subject>Fatty Acids, Nonesterified - metabolism</subject><subject>Female</subject><subject>forecasting</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General aspects</subject><subject>glande mammaire</subject><subject>glandulas mamarias</subject><subject>glicemia</subject><subject>glycaemia</subject><subject>glycemie</subject><subject>Growth Hormone - analogs & derivatives</subject><subject>Growth Hormone - pharmacology</subject><subject>hormonas pituitarias</subject><subject>hormone hypophysaire</subject><subject>Human Growth Hormone</subject><subject>Hydroxybutyrates - metabolism</subject><subject>Lactates - metabolism</subject><subject>Lactation - physiology</subject><subject>lactic acid</subject><subject>mammary glands</subject><subject>Mammary Glands, Animal - blood supply</subject><subject>Mammary Glands, Animal - drug effects</subject><subject>Mammary Glands, Animal - metabolism</subject><subject>matematicas</subject><subject>mathematics</subject><subject>mathematique</subject><subject>nutrient uptake</subject><subject>pituitary hormones</subject><subject>plasma sanguin</subject><subject>plasma sanguineo</subject><subject>Recombinant Proteins - pharmacology</subject><subject>Regression Analysis</subject><subject>technique de prevision</subject><subject>tecnicas de prediccion</subject><subject>trigliceridos</subject><subject>triglyceride</subject><subject>triglycerides</subject><subject>Triglycerides - metabolism</subject><subject>vacas lecheras</subject><subject>vache laitiere</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>0022-0302</issn><issn>1525-3198</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><recordid>eNpdkFtv1DAQRi0EKkvhJ4CCQFweUjy-xPYjqrhUqgRS6bM1cZzdLLkstqOq_x5nsyoST5Y1Z76ZOYS8BnrBodKf9k28uKGUsZJyyj4Y-Ki0VFDqR2QDksmSg9GPyeYBeUqexbjPX2BUnpEzUFJVDDbk6iem5MMYi6ktxjmFzo-pmA8Jf_uivi_SzhcDDgOG-2Lb49gcwR5dwtSN26LBLlfcdBefkyct9tG_OL3n5Pbrl1-X38vrH9-uLj9fl04omUqGLRfIW19x2jRcMkQhjEeulfPK66rSRtbKoaqpE7rmpgbUhre0qhRqyc_JuzX3EKY_s4_JDl10vs_L-WmOVjFZCSF4Bt_8B-6nOYx5NwtaKaCGS5Mps1IuTDEG39pD6JZzLVC7yLZZtj3KtotJa8AeZVude1-eJsz14Jt_navdXH97qmN02LcBR9fFB0wCy9xy0fsV23Xb3V0XvI0D9n0OhWW4EhbAcmWWwFcr2eJkcRty2O0NGMMoUMWp5n8BW1qdzg</recordid><startdate>19911101</startdate><enddate>19911101</enddate><creator>Miller, P. S</creator><creator>Reis, B. L</creator><creator>Calvert, C. C</creator><creator>DePeters, E. J</creator><creator>Baldwin, R. 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S ; Reis, B. L ; Calvert, C. C ; DePeters, E. J ; Baldwin, R. L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c475t-2af34a3fe630dd352aa449ea387ce7e866895b7ca7b0c48b39b1a893f0667a853</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>3-Hydroxybutyric Acid</topic><topic>absorcion de substancias nutritivas</topic><topic>absorption de substances nutritives</topic><topic>acetate</topic><topic>acetates</topic><topic>Acetates - metabolism</topic><topic>acetatos</topic><topic>acide gras</topic><topic>acide lactique</topic><topic>acido lactico</topic><topic>acidos grasos</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose - metabolism</topic><topic>blood plasma</topic><topic>Cattle - physiology</topic><topic>cholesterol</topic><topic>Cholesterol - metabolism</topic><topic>colesterol</topic><topic>dairy cows</topic><topic>fatty acids</topic><topic>Fatty Acids, Nonesterified - metabolism</topic><topic>Female</topic><topic>forecasting</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>General aspects</topic><topic>glande mammaire</topic><topic>glandulas mamarias</topic><topic>glicemia</topic><topic>glycaemia</topic><topic>glycemie</topic><topic>Growth Hormone - analogs & derivatives</topic><topic>Growth Hormone - pharmacology</topic><topic>hormonas pituitarias</topic><topic>hormone hypophysaire</topic><topic>Human Growth Hormone</topic><topic>Hydroxybutyrates - metabolism</topic><topic>Lactates - metabolism</topic><topic>Lactation - physiology</topic><topic>lactic acid</topic><topic>mammary glands</topic><topic>Mammary Glands, Animal - blood supply</topic><topic>Mammary Glands, Animal - drug effects</topic><topic>Mammary Glands, Animal - metabolism</topic><topic>matematicas</topic><topic>mathematics</topic><topic>mathematique</topic><topic>nutrient uptake</topic><topic>pituitary hormones</topic><topic>plasma sanguin</topic><topic>plasma sanguineo</topic><topic>Recombinant Proteins - pharmacology</topic><topic>Regression Analysis</topic><topic>technique de prevision</topic><topic>tecnicas de prediccion</topic><topic>trigliceridos</topic><topic>triglyceride</topic><topic>triglycerides</topic><topic>Triglycerides - metabolism</topic><topic>vacas lecheras</topic><topic>vache laitiere</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Miller, P. 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S</au><au>Reis, B. L</au><au>Calvert, C. C</au><au>DePeters, E. J</au><au>Baldwin, R. L</au><aucorp>University of Nebraska, Lincoln</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Patterns of nutrient uptake by the mammary glands of lactating dairy cows</atitle><jtitle>Journal of dairy science</jtitle><addtitle>J Dairy Sci</addtitle><date>1991-11-01</date><risdate>1991</risdate><volume>74</volume><issue>11</issue><spage>3791</spage><epage>3799</epage><pages>3791-3799</pages><issn>0022-0302</issn><eissn>1525-3198</eissn><coden>JDSCAE</coden><notes>L</notes><notes>L50</notes><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Twenty-one multiparous lactating dairy cows with previous 305-d milk production records varying from 5900 to 13,600 kg were used to examine patterns of nutrient uptake by the mammary glands. On d 71 and continuing until d 126 of lactation, animals were injected daily with 40 mg of sometribove (bST group) or bicarbonate buffer (control group). Arterial and venous blood plasma samples were collected over a 12-h period on d 35, 70, 105, and 126 of lactation. Regression equations developed to evaluate linear effects of plasma arterial concentrations on net arterial-venous difference across the mammary glands demonstrated that, for acetate, NEFA, and D-beta-hydroxybutyrate, plasma arterial concentration accounted for over 50% of variation in uptake by the mammary glands. Additionally, a sigmoidal equation fitted the relationship between D-beta-hydroxybutyrate plasma arterial concentration and mammary gland uptake (r2 = 0.70). Triacylglyceride concentration was less effective in predicting uptake (r2 = 0.25). Administration of bST did not alter patterns of nutrient uptake, but a fourfold increase in NEFA uptake was predicted for bST-treated cows from this study, using NEFA concentrations from the literature. These observations indicate that plasma concentration of acetate, NEFA, D-beta-hydroxybutyrate, and triacylglyceride are major determinants of uptake by the mammary glands. Factors other than plasma concentration, such as mammary gland biosynthetic capacity, availability of other nutrients, and blood flow, determine uptakes of glucose, lactate, and total and free cholesterol (r2 less than or equal to 0.03).</abstract><cop>Savoy, IL</cop><pub>Am Dairy Sci Assoc</pub><pmid>1757621</pmid><doi>10.3168/jds.S0022-0302(91)78571-8</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of dairy science, 1991-11, Vol.74 (11), p.3791-3799 |
| issn | 0022-0302 1525-3198 |
| language | eng |
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| source | EZB Electronic Journals Library |
| subjects | 3-Hydroxybutyric Acid absorcion de substancias nutritivas absorption de substances nutritives acetate acetates Acetates - metabolism acetatos acide gras acide lactique acido lactico acidos grasos Animals Biological and medical sciences Blood Glucose - metabolism blood plasma Cattle - physiology cholesterol Cholesterol - metabolism colesterol dairy cows fatty acids Fatty Acids, Nonesterified - metabolism Female forecasting Fundamental and applied biological sciences. Psychology General aspects glande mammaire glandulas mamarias glicemia glycaemia glycemie Growth Hormone - analogs & derivatives Growth Hormone - pharmacology hormonas pituitarias hormone hypophysaire Human Growth Hormone Hydroxybutyrates - metabolism Lactates - metabolism Lactation - physiology lactic acid mammary glands Mammary Glands, Animal - blood supply Mammary Glands, Animal - drug effects Mammary Glands, Animal - metabolism matematicas mathematics mathematique nutrient uptake pituitary hormones plasma sanguin plasma sanguineo Recombinant Proteins - pharmacology Regression Analysis technique de prevision tecnicas de prediccion trigliceridos triglyceride triglycerides Triglycerides - metabolism vacas lecheras vache laitiere Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Patterns of nutrient uptake by the mammary glands of lactating dairy cows |
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