Patterns of nutrient uptake by the mammary glands of lactating dairy cows

Twenty-one multiparous lactating dairy cows with previous 305-d milk production records varying from 5900 to 13,600 kg were used to examine patterns of nutrient uptake by the mammary glands. On d 71 and continuing until d 126 of lactation, animals were injected daily with 40 mg of sometribove (bST g...

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Bibliographic Details
Published in:Journal of dairy science 1991-11, Vol.74 (11), p.3791-3799
Main Authors: Miller, P. S, Reis, B. L, Calvert, C. C, DePeters, E. J, Baldwin, R. L
Format: Article
Language:English
Subjects:
3-Hydroxybutyric Acid
absorcion de substancias nutritivas
absorption de substances nutritives
acetate
acetates
Acetates - metabolism
acetatos
acide gras
acide lactique
acido lactico
acidos grasos
Animals
Biological and medical sciences
Blood Glucose - metabolism
blood plasma
Cattle - physiology
cholesterol
Cholesterol - metabolism
colesterol
dairy cows
fatty acids
Fatty Acids, Nonesterified - metabolism
Female
forecasting
Fundamental and applied biological sciences. Psychology
General aspects
glande mammaire
glandulas mamarias
glicemia
glycaemia
glycemie
Growth Hormone - analogs & derivatives
Growth Hormone - pharmacology
hormonas pituitarias
hormone hypophysaire
Human Growth Hormone
Hydroxybutyrates - metabolism
Lactates - metabolism
Lactation - physiology
lactic acid
mammary glands
Mammary Glands, Animal - blood supply
Mammary Glands, Animal - drug effects
Mammary Glands, Animal - metabolism
matematicas
mathematics
mathematique
nutrient uptake
pituitary hormones
plasma sanguin
plasma sanguineo
Recombinant Proteins - pharmacology
Regression Analysis
technique de prevision
tecnicas de prediccion
trigliceridos
triglyceride
triglycerides
Triglycerides - metabolism
vacas lecheras
vache laitiere
Vertebrates: anatomy and physiology, studies on body, several organs or systems
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Summary:Twenty-one multiparous lactating dairy cows with previous 305-d milk production records varying from 5900 to 13,600 kg were used to examine patterns of nutrient uptake by the mammary glands. On d 71 and continuing until d 126 of lactation, animals were injected daily with 40 mg of sometribove (bST group) or bicarbonate buffer (control group). Arterial and venous blood plasma samples were collected over a 12-h period on d 35, 70, 105, and 126 of lactation. Regression equations developed to evaluate linear effects of plasma arterial concentrations on net arterial-venous difference across the mammary glands demonstrated that, for acetate, NEFA, and D-beta-hydroxybutyrate, plasma arterial concentration accounted for over 50% of variation in uptake by the mammary glands. Additionally, a sigmoidal equation fitted the relationship between D-beta-hydroxybutyrate plasma arterial concentration and mammary gland uptake (r2 = 0.70). Triacylglyceride concentration was less effective in predicting uptake (r2 = 0.25). Administration of bST did not alter patterns of nutrient uptake, but a fourfold increase in NEFA uptake was predicted for bST-treated cows from this study, using NEFA concentrations from the literature. These observations indicate that plasma concentration of acetate, NEFA, D-beta-hydroxybutyrate, and triacylglyceride are major determinants of uptake by the mammary glands. Factors other than plasma concentration, such as mammary gland biosynthetic capacity, availability of other nutrients, and blood flow, determine uptakes of glucose, lactate, and total and free cholesterol (r2 less than or equal to 0.03).
ISSN:0022-0302
1525-3198
DOI:10.3168/jds.S0022-0302(91)78571-8