Imaging Physiologic Dysfunction of Individual Hippocampal Subregions in Humans and Genetically Modified Mice

We have developed a variant of functional magnetic resonance imaging (fMRI) designed to be sensitive to static neuronal function. This method is based on resting instead of dynamic changes in oxygen-dependent signal and therefore allows for a spatial resolution that can detect signal from different...

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Bibliographic Details
Published in:Neuron (Cambridge, Mass.) Mass.), 2000-12, Vol.28 (3), p.653-664
Main Authors: Small, Scott A., Wu, Ed X., Bartsch, Dusan, Perera, Gerard M., Lacefield, Clay O., DeLaPaz, Robert, Mayeux, Richard, Stern, Yaakov, Kandel, Eric R.
Format: Article
Language:English
Subjects:
Aged
Animals
Brain Diseases - complications
Brain Diseases - diagnosis
Brain Diseases - physiopathology
Cognition Disorders - diagnosis
Cognition Disorders - etiology
Cognition Disorders - physiopathology
Hippocampus - metabolism
Hippocampus - pathology
Hippocampus - physiopathology
Humans
Magnetic Resonance Imaging - methods
Memory
Memory Disorders - diagnosis
Memory Disorders - etiology
Memory Disorders - physiopathology
Mice
Mice, Inbred C57BL
Mice, Transgenic
Neurons - metabolism
Oxygen - metabolism
Predictive Value of Tests
Sensitivity and Specificity
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Summary:We have developed a variant of functional magnetic resonance imaging (fMRI) designed to be sensitive to static neuronal function. This method is based on resting instead of dynamic changes in oxygen-dependent signal and therefore allows for a spatial resolution that can detect signal from different hippocampal subregions in human subjects as well as in mice. We found that hippocampal signal was significantly diminished in elderly subjects with memory decline compared to age-matched controls, and different subjects showed dysfunction in different subregions. Among healthy elders, signal intensity from the subiculum was correlated selectively with memory performance. This method does not require an activation task; it can be used in anesthetized normal and in genetically modified and cognitively impaired mice. In mice the signal was found to be sufficiently sensitive to detect functional changes in the absence of underlying anatomical changes.
ISSN:0896-6273
1097-4199
DOI:10.1016/S0896-6273(00)00144-6