Synthesis and cytotoxic activity of 2-dialkylaminoethylamino substituted xanthenone and thioxanthenone derivatives

The synthesis and biological evaluation of some new pyranoxanthenones and pyranothioxanthenones, substituted with flexible amino side-chains, and their evaluation as potential antitumor agents is described. The cytotoxic activity of the compounds and their eventual selective effect on a phase of the...

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Bibliographic Details
Published in:Farmaco (Società chimica italiana : 1989) 2000-06, Vol.55 (6), p.455-460
Main Authors: Kostakis, Ioannis, Ghirtis, Konstantinos, Pouli, Nicole, Marakos, Panagiotis, Skaltsounis, Alexios-Leandros, Leonce, Stephane, Caignard, Daniel H, Atassi, Ghanem
Format: Article
Language:English
Subjects:
2-Dialkylaminoethylamino thioxanthenones
2-Dialkylaminoethylamino xanthenones
Animals
Antineoplastic agents
Antineoplastic Agents - chemical synthesis
Antineoplastic Agents - pharmacology
Biological and medical sciences
Cell Cycle - drug effects
Cell-cycle selectivity
Cytotoxic activity
Drug Screening Assays, Antitumor
Fumarates - chemical synthesis
General aspects
Leukemia L1210 - drug therapy
Medical sciences
Mice
Pharmacology. Drug treatments
Tumor Cells, Cultured
Xanthenes - chemical synthesis
Xanthenes - pharmacology
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Summary:The synthesis and biological evaluation of some new pyranoxanthenones and pyranothioxanthenones, substituted with flexible amino side-chains, and their evaluation as potential antitumor agents is described. The cytotoxic activity of the compounds and their eventual selective effect on a phase of the cell cycle were evaluated in vitro, using the murine lymphocytic L1210 leukemia cell line. The new aminoderivatives exhibited highly potent cytotoxicity against the leukemia L1210 cell line when compared to acronycine. All the compounds induced a partial accumulation of cells in the G2+M phase of the cell cycle.
ISSN:0014-827X
1879-0569
DOI:10.1016/S0014-827X(00)00068-9